Three new cases of gastroduodenal Crohn's disease are presented, two with obstruction and one with massive gastrointestinal bleeding. Of the 124 cases reported in the literature up to 1972, only four had massive gastrointestinal bleeding. An accurate preoperative diagnosis is difficult. When peptic epigastric distress and retention type of vomiting are associated with diarrhea, the diagnosis of gastroduodenal Crohn's disease should be strongly considered. A surgical bypass procedure or resection is indicated when symptoms of duodenal obstruction do not respond to medical treatment.