Variant Angina in the Setting of Hypothyroidism and Beta Blockade: A Proposed Mechanism

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Coronary artery spasm can occur in the presence of excessive alpha-adrenergic tone. A decrease in protective coronary vasodilator substance and enhanced alpha-adrenergic responsiveness, which occurs in the setting of hypothyroidism and beta blockade, predisposes to coronary artery spasm. The case presented supports these concepts.

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