Combined Oral L-Dopa and Propranolol for Growth Hormone Provocation

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Abstract

A convenient test of growth hormone (GH) provocation using oral doses of L-dopa and propranolol (L+P) is compared with insulin-induced hypoglycemia (IIH) in 28 children and adolescents with short stature. In eight of these children, growth hormone deficiency was diagnosed when GH failed to rise above 7 ng/ml. The GH levels of the remaining GH-responsive children were significantly higher after administration of L+P (P < .05) when compared with IIH given before L+P on the same morning or on a separate day.

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