A Comparative Study of Ketorolac (Toradol) and Magnesium Sulfate for Arrest of Preterm Labor

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Abstract

Background.

We evaluated the efficacy and safety of ketorolac (Toradol).

Methods.

In this prospective trial, 88 women in confirmed preterm labor at ≤32 weeks' gestation were randomized to receive magnesium sulfate given as an initial 6 g intravenous bolus followed by continuous infusion therapy (2 to 6 g/hr) or intramuscularly administered ketorolac (60 mg loading dose) followed by 30 mg every 6 hours for a maximum of 24 hours.

Results.

The study groups were similar with respect to age, parity, cervical status, and gestational age on admission. Ketorolac was more rapid (2.71 hr ±2.16) in the arrest of preterm labor than was magnesium sulfate (6.22 hr ± 5.65). No patient required discontinuance of either drug due to adverse effects. There was no difference in the incidence of neonatal complications between the two groups.

Conclusion.

In gestations with preterm labor at <32 weeks, ketorolac appears to be an appropriate first-line tocolytic agent.

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