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Principles of general and shoulder conditioning exercises for the healthy late adolescent and adult baseball player start this presentation. Subsequently, common throwing shoulder and elbow problems are discussed in a rehabilitative context. The reader will acquire skills in diagnosing and rehabilitating surgical and nonsurgical conditions of rotator cuff tendonitis, partial rotator cuff tears, superior labrum anterior posterior (SLAP) lesions, throwing acquired decreased shoulder internal rotation (TADSIR), microanterior shoulder instability, posterior elbow impingement, and medial elbow disorders. The alliance between athletic trainers, physical therapists, team physicians, and coaches is critical in returning mature serious baseball players to a game-ready state.