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A new differential lattice Boltzmann equation (LBE) is presented in this work, which is derived from the standard LBE by using Taylor series expansion only in spatial direction with truncation to the second-order derivatives. The obtained differential equation is not a wave-like equation. When a uniform grid is used, the new differential LBE can be exactly reduced to the standard LBE. The new differential LBE can be applied to solve irregular problems with the help of coordinate transformation. The present scheme inherits the merits of the standard LBE. The 2-D driven cavity flow is chosen as a test case to validate the present method. Favorable results are obtained and indicate that the present scheme has good prospects in practical applications.