A Solid-phase Radioimmunoassay for the Detection of Antibodies to Treponema pallidum

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Abstract

A solid-phase radioimmunoassay (RIA) procedure was developed for the detection of antibodies to Treponema pallidum. The source of antigen used was T. pallidum (Nichols strain), which was specifically bound to the solid phase by use of rabbit antibody to T. pallidum (Nichols strain). The solid-phase system for this RIA test is the well of a microtitcr plate. Preliminary data suggest that the RIA procedure is sensitive and specific and might be a useful addition to the research tools and scrologic tests used in the study and diagnosis of syphilis.

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