Synthesis of various secosteroidal macrocycles by ring-closing metathesis

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Abstract

We set out to describe an efficient and versatile method for preparing secosteroidal macrocycles from cholic acid, via an oxidative ring-expansion/ring-opening sequence and a ring-closing metathesis reaction as the key steps. The characteristic 1H and 13C NMR spectroscopic features of the synthesized compounds are reported.

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