New cytotoxic steroids from the leaves ofClerodendrum trichotomum

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Abstract

Graphical abstract

Five new (2–6) and two known (1 and 7) steroids were isolated from the leaves of Clerodendrum trichotomum. Steroids 2 and 5 exhibited moderate cytotoxicity in vitro against HeLa cell line.

A phytochemical investigation of the leaves of Clerodendrum trichotomum led to the isolation of five new (2–6) and two known (1 and 7) steroids, whose structures and relative configurations were elucidated by comprehensive spectroscopic analysis and by comparison of their NMR data with those of related compounds. Steroids 2 and 5 exhibited moderate cytotoxicity in vitro against HeLa cell line.

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