Synthesis of 23-deoxy-25-epinorth unit of cephalostatin 1 via reductive and oxidative modifications of hecogenin acetate

    loading  Checking for direct PDF access through Ovid


An efficient synthesis of the 23-deoxy-25-epi north unit of cephalostatin 1 has been achieved in 17 steps via reductive and oxidative functionalizations of hecogenin acetate with an overall yield of 3.8%. This synthesis features transetherification-mediated E-ring opening, D-ring oxidation, hemiketalization-mediated E-ring closure, and stereoselective 5/5-spiroketalization.

Related Topics

    loading  Loading Related Articles