Two new cytotoxic steroids from the Chinese soft coralSinulariasp.

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Graphical abstractHighlightsFour steroids were isoated from the Chinese soft coral Sinularia sp.First reported natural steroid bearing a dihydrofuran at ring E.Modified Mosher's method determined the absolute of ximaosteroid F.Ximaosteroid E and ximaosteroid F showed significant selective cytotoxicity against the HL-60 cell line with IC50 values of 1.79 and 4.03 μM, respectively.Two new steroids, ximaosteroid E (1) and ximaosteroid F (2), along with two known related compounds (3 and 4), were isolated from the Chinese soft coral Sinularia sp. Notably, 1 possesses an uncommon dihydrofuran group. Their structures were established from extensive spectroscopic analyses and comparisons of their spectral data with those reported in the literature. The absolute configuration of 2 was determined by applying the modified Mosher's method. In bioassay, compounds 1, 2, and 4 showed significant cytotoxicity against the HL-60 tumor cell line with IC50 values of 1.79, 4.03 and 0.69 μM, respectively.

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