Science Translational Medicine. 9(396):, JUNE 28, 2017 DOI: 10.1126/scitranslmed.aan6729 , PMID: 28659441 Issn Print: 1946-6234 Publication Date: June 28, 2017 Print Epigenetics make transient states of cancer therapy resistance permanent Kristopher Sarosiek; + Author Information John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Email: firstname.lastname@example.org Checking for direct PDF access through Ovid Abstract Resistance to targeted cancer therapies is mediated by stabilization of transient insensitive states.