Calcium in Ischemic Cell Death

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Abstract

Background

This review article deals with the role of calcium in ischemic cell death. A calcium-related mechanism was proposed more than two decades ago to explain cell necrosis incurred in cardiac ischemia and muscular dystrophy. In fact, an excitotoxic hypothesis was advanced to explain the acetylcholine-related death of muscle end plates. A similar hypothesis was proposed to explain selective neuronal damage in the brain in ischemia, hypoglycemic coma, and status epilepticus.

Conclusions

Calcium is one of the triggers involved in ischemic cell death, whatever the mechanism. (Stroke. 1998;29:705-718.)

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