Abstract WMP110: Improvement in Cortical Versus Subcortical Perfusion After Superficial Temporal Artery- Middle Cerebral Artery (MCA) Bypass in Patients With Severe Stenosis of Intracranial Carotid and MCA

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Background and Objective: The role of superficial temporal artery-middle cerebral artery (STA-MCA) bypass in patients with symptomatic intracranial steno-occlusive disease has been evaluated scarcely. We have recently reported the improvement in clinical and various cerebral hemodynamic parameters after STA-MCA bypass surgery for severe steno-occlusive disease of intracranial internal carotid (ICA) or middle cerebral artery (MCA) and impaired cerebral vasodilatory reserve (CVR). Using acetazolamide challenged hexamethylpropyleneamine-oxime single-photon emission computed tomography (HMPAO-SPECT), we evaluated the differential improvement in metabolic perfusion in cortical and subcortical structures after STA-MCA bypass surgery.

Methods: Patients with severe steno-occlusive disease of intracranial ICA or MCA underwent transcranial Doppler (TCD) for CVR assessment using breath-holding index (BHI). Patients with impaired BHI (<0.69) were further evaluated with acetazolamide-challenged SPECT and STA-MCA bypass surgery was offered to patients with impaired CVR on SPECT. All patients underwent SPECT at 4±1 months. Using automated image analyzer, we evaluated differences in metabolic perfusion in cortical and subcortical regions.

Results: Of the 126 patients (80 male, mean age 56yrs; range 23-78yrs) that fulfilled our inclusion criteria, 84 (67%) showed impaired CVR on SPECT. Fifty (60%) of them underwent STA-MCA bypass surgery. HMPAO-SPECT repeated 4±1 months after surgery showed significant improvement in all cases. Significantly better improvement (14.5%) in cerebral perfusion was noted in the cortical regions as compared to the subcortical regions (4.5%, p<0.005).

Conclusion: STA-MCA bypass surgery in carefully selected patients with symptomatic severe intracranial steno-occlusive disease results in significant improvement in cerebral perfusion, especially in the cortical regions.

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