Abstract WP211: The Association Between Arterial Stiffness and Perivascular Space Topography in Stroke Patients

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Background: Arterial stiffness aggravation is known to increase cerebral small vessel disease burden. We investigated the association between brachial-ankle pulse wave velocity (baPWV) and the topography of MRI visible perivascular space in acute stroke population.

Method: We analyzed clinical and laboratory data of acute ischemic stroke or transient ischemic attack patients who had been admitted to Chung-Ang University Hospital within 7 days after symptom onset between January 1st 2014 and May 31th 2015. We included those patients who underwent both brain MR imaging including T2 weighted sequence and baPWV. The topography of perivascular space was examined in basal ganglia and centrum semiovale level with validating scale (score 0-4), and dichotomized as low (score3).

Result: A total of 481 patients were included (mean age 68.2±12.3, 44.7% male). When the distribution of baPWV were divided into quartile, the proportions of high PVS in basal ganglia was 10%, 20%, 40% and 40%, respectively. The proportion of high PVS in centrum semiovale was 20%, 40%, 36%, and 49%, respectively. Multivariate logistic regression analysis revealed that the high degree of basal ganglia PVS was associated with baPWV>2255cm/s (odds ratio 1.7, confidence interval 1.0-2.7, p=0.048) after adjusting age>70 years, hypertension, current smoking status and previous stroke history. The high degree of centrum semiovale PVS showed marginal association with baPWV>2255cm/s (odds ratio=1.4, confidence interval 0.9-2.3, p=0.137) after adjusting age>70 years and hypertension.

Conclusion: Our pilot study suggests potential pathophysiological association between arterial stiffness and PVS topography.

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