Objective: To characterize the neuropsychological profile of sporadic cerebral amyloid angiopathy (CAA) patients without dementia and to determine the association between cognitive performance in different domains and neuroimaging lesions characteristic of CAA.
Methods: Forty-eight CAA patients were compared to 138 cognitively normal subjects (CN) using a standard neuropsychological test battery designed to assess the cognitive profile in CAA patients without dementia. Total brain volume (TBV), white matter hyperintensities (WMH), number of cerebral microbleeds (CMBs), hippocampal volume (HV) and the presence of cerebral superficial siderosis (cSS) of all CAA patients were measured. The association between these neuroimaging markers and neuropsychological performance in different cognitive domains in the CAA group were analyzed.
Results: Patients with CAA had significantly worse performance on all individual neuropsychological domain tested when compared to the CN group. The cognitive decline of CAA patients was most noticeable in tests for processing speed (Z score -1.84±1.50), then followed by executive function (Z score -1.03±1.04), semantic fluency (Z score -0.71±1.07), episodic memory (Z score -0.68±1.08), and attention (Z score -0.48±1.00). Total brain volume of the CAA patients was correlated with processing speed (β=0.358, P=0.034) and executive function (β=0.507, P=0.002).
Conclusion: Non-demented patients with CAA had cognitive deficits in multiple areas. Lower total brain volume was related to slower processing speed and worse executive function.