Abstract WMP100: Topographical Distribution of Lacunes in Cerebral Amyloid Angiopathy and Deep Hypertensive Intracerebral Hemorrhage

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Background/Aims: To evaluate whether the burden of lacunes located at deep and lobar brain regions, would differ between intracerebral hemorrhage patients (ICH) with cerebral amyloid angiopathy (CAA) vs patients with strictly deep cerebral microbleeds (CMB) and ICH (Deep HTN-ICH).

Methods: We defined lobar and deep lacunes similar to the topographic distribution used for ICH and microbleeds. We then compared their distribution between CAA and Deep HTN-ICH patients. The independent associations of lacune location (lobar vs deep) with diagnosis of CAA-ICH and Deep HTN-ICH were evaluated using multivariable models. The relationship between lobar and deep lacunes and WMH volume was evaluated using partial correlation analyses adjusting for age and by means of a validated visual scale.

Results: In our cohort of 316 ICH patients, lobar lacunes were more commonly present in CAA (20.4% vs 5.7% in Deep HTN-ICH, p<0.001; see figure) while deep lacunes more frequent in Deep HTN-ICH patients (15.2% vs 2.1%, p<0.001; see figure). After correction for demographics, clinical and neuroimaging markers of SVD, lobar lacunes were associated with CAA diagnosis (p=0.023), while deep lacunes with Deep HTN-ICH (p<0.001). Lobar lacunes in 80% of the cases were at least in contact with WMH and after adjustment for age they were highly correlated to WMH volume (r=0.52, p<0.001).

Conclusions: Lobar lacunes are associated with CAA whereas deep lacunes are more frequent in patients with Strictly deep CMBs and ICH, they can thus be clinically useful in the appropriate context. Lobar lacunes seem to have a close relationship with WMH suggesting a possible common origin.

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