Abstract WP201: Sub-analysis of Japanese Versus Non-japanese on Background Characteristics and One-year Outcomes in Tiaregistry.org

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Background and Purpose: TIAregistry.org is an international prospective registry in patients with TIA or minor stroke (mRS 0 or 1) within 7 days after the onset. Main analysis of one-year follow-up data have been reported (N Engl J Med 2016;374:1533-42). We performed Japanese vs non-Japanese sub-analysis on the baseline and one-year follow-up data.Methods: Patients were classified into two groups according to their countries of origin (Japanese and non-Japanese). All comparisons between the two groups were adjusted on age, sex and mRS. Variables included demographic characteristics, intracranial and extracranial arterial stenosis, acute infarcts, TOAST classification, ABCD2 score, and time to first contact. We compared the 1-year event rates of cardiovascular death, non-fatal stroke, and non-fatal acute coronary syndrome between the two groups using Cox proportional hazard models.Results: A total of 4,583 patients were included in the analysis. From them, 345 (7.5%) were Japanese. Proportion of patients with mRS 1 was higher in Japanese (58.5% vs 27.9%, p <0.001). The prevalence of acute infarct was higher for Japanese (73.9% vs 29.8%, p <0.001). Intracranial arterial stenosis >50% was more common in Japanese (19.6% vs 12.9%, p = 0.01). Distribution of ABCD2 score was also different between Japanese and non-Japanese (20.1% vs 33.5% in scores 0-3, 28.6% vs 18.3% in scores 6 and 7, p = 0.02 in total). Time to first contact <24 hours was fewer in Japanese (80.0% vs 88.2%, P <0.001). Composite event rate of cardiovascular death, nonfatal stroke, nonfatal acute coronary syndrome was 7.7% in Japanese and 6.0% in non-Japanese (p = 0.18), while nonfatal stroke rate was higher for the Japanese patients (7.5% vs 4.4%, p = 0.008).Conclusions: Higher risk conditions in baseline characteristics as well as delay of time to contact, and a higher one-year stroke rate were identified in Japanese patients enrolled in this registry.

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