Reduction of Hyperthermic Ischemic Acidosis by a Conditioning Event in Cats

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Abstract

We investigated the effects of multiple episodes of cerebral ischemia on intracellular brain pH using in vivo phosphorus-31 nuclear magnetic resonance spectroscopy. Four cats were subjected to two 16-minute episodes of complete global cerebral ischemia 6 hours apart; the second episode occurred under hyperthermic conditions (mean±SD body temperature 40.8 ±0.4° C). Intracellular pH in these four cats was compared with that in nine cats subjected to a single 16-minute episode of complete global cerebral ischemia under hyperthermic conditions (mean±SD body temperature 40.6±0.2° C). Intracellular pH during hyperthermic recirculation was significantly (/? < 0.03) greater in cats subjected to a previous ischemic event than that in cats subjected to only a single hyperthermic ischemic event. We speculate that the induction of heat shock proteins by an initial ischemic event may protect brain tissue from further ischemic insult. (Stroke 1989;20:1357–1360)

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