From the Clinical Trials Research Unit (V.L.F.), School of Population Health, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand; the Department of Neurology (N.E.A.), Auckland Hospital, Auckland, New Zealand; the Department of Neurology (G.J.E.R., A.A., J.v.G.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), University Medical Center Utrecht, The Netherlands; and the Clinical Trial Service Unit and Epidemiological Studies Unit (D.A.B.), Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom.