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Vascular compression of the duodenum is also known as superior mesenteric artery syndrome (SMA syndrome) or Wilkie syndrome. This is a rare condition that is characterized by compression of the third portion of the duodenum by the SMA as it passes over this portion of the duodenum. Duodenojejunostomy is usually considered to be the treatment of choice. We recently experienced the case of a very thin 19-year-old female with the diagnosis of SMA syndrome. We started nasogastric tube decompression and total parenteral nutrition, but that was ineffective; we then performed laparoscopic duodenojejunostomy. We herein report on this successful laparoscopic duodenojejunostomy procedure along with a review of the relevant literature.