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This study aimed to explore the feasibility and safety of laparoscopic retreatment for residual gallbladders following open techniques, and outline strategies for successful reintervention.From January 2008 to December 2015, the clinical and follow-up data of 32 patients who underwent laparoscopic reintervention for residual gallbladders following open techniques were retrospectively analyzed and summarized.Of all patients, 4 underwent 2 laparotomic surgeries; 6 had choledocholithiasis and underwent endoscopic retrograde cholangiopancreatography. All procedures for residual gallbladders, except 1, were successfully completed by laparoscopy using 3 to 6 trocars. The mean operative time, mean blood loss, and duration of hospital stay were 51.9±14.6 minutes, 30 mL, and 3 to 8 days, respectively. One patient had bilious drainage, lasting up to day 8. All patients remained symptom free, and no mortality and major morbidity were observed on a mean follow-up of at least 6 months.Laparoscopic management is feasible and safe for residual gallbladders following open techniques, subject to availability of expertise with well-defined strategies.