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The aim of this study was to evaluate the results of laparoscopic cholecystectomy (LC) in patients with xanthogranulomatous cholecystitis (XGC) compared with patients without XGC.A retrospective study was performed including patients who had undergone elective LC between January 2003 and November 2017. Results of patients with XGC (25) were compared with those of patients without XGC (2181) with respect to operative time, conversion rate, drain use, postoperative complications, and postoperative stay.The mean operative times in patients with and without XGC were 112.8 and 66.3 minutes, respectively (P=0.001). The conversion rate was 36% in patients with XGC and 3.89% in patients without XGC (P=0.001). Drains were used in 76% of patients with XGC and in 24% of patients without XGC (P=0.001). Postoperative complication rate was 16% and 9.9% in patients with and without XGC, respectively (P=0.309). Mean postoperative stays in patients with and without XGC were 4.3 and 2.3 days, respectively (P=0.001).LC in patients with XGC is associated with significantly longer operative time, higher conversion rate, greater drain use, and longer postoperative stay compared with patients without XGC.