Sugarcane being an important cash crop of India, is cultivated in different Agro-Climatic condition. Weeds are growing along with sugarcane and limits the cane and sugar yield according to the species and intensity. Shift in weed flora was observed due to following the same method of weed management practice for long period. Sedges like Cyperus sp. has been shifted from annuals and broad-leaved weeds by spraying the pre- emergence herbicide viz.,Atrazine. The sedges can also be controlled by spraying of total weed killer (Glyphosate). Further, the nature has encouraged the weeds of twining habit, which are germinated and growing by climbing on the sugarcane stalks after the earthing up operation. These weeds are posing several problems like blocking the sunlight to the cane crop by spreading their branches on the top plane. It also gives trouble to the harvesting labour and increasing the cost of operation. Hence, twining weeds are to be completely controlled by following a suitable measures. With this objective a study was carried out during special season of 2001-02 and 2002-03 at Sugarcane Research Station, Sirugamani, Trichirappalli district where cane is cultivated under flow irrigated condition. Among the different weed management methods, spraying of pre-emergence spray of atrazine @ 1.0 kg/ha followed by post-emergence spray of 2,4-D Na salt @ 1.0 kg/ha on 110 DAP had high weed control efficiency onIpomoea sepiariaand registered the highest cane and sugar yield.