Vitamin D treatment abrogates the inflammatory response in paraquat-induced lung fibrosis


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Abstract

A high incidence of intentional or accidental paraquat (PQ) ingestion is related to irreversible lung fibrosis and no effective therapy is currently available. Vitamin D has emerged with promising results as an immunomodulatory molecule when abrogating the inflammatory responses of lung diseases. Therefore, we have investigated the role of vitamin D treatments on PQ-induced lung fibrosis in male C57/BL6 mice. Lung fibrosis was induced by a single injection of PQ (10mg/kg; i.p.). The control group received PQ vehicle. Seven days later, after the PQ injection or the vehicle injection, the mice received vitamin D (5μg/kg, i.p., once a day) or vehicle, for a further 7days. Twenty-four hours after the last dose of vitamin D or the vehicle, the analysis were performed. The vitamin D treatments reduced the number of leukocytes in their BALF and they decreased the IL-6, IL-17, TGF-beta and MMP-9 levels and the abrogated collagenase deposits in their lung tissues. Conversely, the vitamin D treatments increased the resolvin D levels in their BALF. Moreover, their tracheal contractility was also significantly reduced by the vitamin D treatments. Altogether, the data that was obtained showed a promising use of vitamin D, in treating the lung fibrosis that had been induced by the PQ intoxications. This may improve its prognostic use for a non-invasive and low cost therapy.HIGHLIGHTSVitamin D seems to be an effective treatment in paraquat-induced lung fibrosis.Vitamin D ameliorates paraquat-induced lung fibrosis by resolvin D-mechanism.Vitamin D ameliorates paraquat-induced lung fibrosis by reduction of TGF-β and MMP9.Vitamin D reduces tracheal contractility in paraquat-induced lung fibrosis.

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