Comparison of tissue reactions in the tracheal mucosa surrounding a bioabsorbable and silicone airway stents

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Abstract

Background.

Treatment of tracheobronchial stenosis is problematic. Conservative methods include stenting the stenotic area, but an ideal stent has not yet been developed. Bioabsorbable airway stents offer benefits; the extraction of the device is unnecessary, and the airway preserves its normal function after stent resorption. The aim of this study was to examine the suitability of self-reinforced poly-l-lactide as a material for an airway stent.

Methods.

A spiral airway stent made of 0.7-mm wire of self-reinforced poly-l-lactide was implanted operatively in 9 rabbits intratracheally; silicone stents served as controls.

Results.

Silicone stents had a tendency to become stenosed with encrustation material and to develop a hyperplastic polyp at both ends. Self-reinforced poly-l-lactide stents were well tolerated and caused no foreign body reaction, and they had a tendency to penetrate into the tracheal wall. They had disappeared at the end of the follow-up of 10 months.

Conclusions.

This experimental study showed that bioabsorbable self-reinforced poly-l-lactide is a promising material for an airway stent for treatment of airway stenosis.

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