While although full-compartment fasciotomy is unquestionably the best treatment for acute compartment syndrome, it is not a benign procedure. It leaves a large open wound that should be left open for at least 2 to 3 days. The outward pressure from swollen muscle and skin retraction serves to increase the dimensions of these wounds, which makes delayed primary closure challenging and often not possible in the most common fasciotomy site—the leg. This study discusses recent advances in the management of fasciotomy wounds that can reduce the morbidity of this procedure. Negative pressure wound therapy and dermatotraction are 2 important innovations, which improve overall outcomes.