A general overview of transfemoral prosthetics is presented to improve collaboration and optimize patient outcomes. Incorporating the rehabilitation team including physical therapist, prosthetist, and counselors into the perioperative phases helps prepare the patient for prosthetic treatment and reduces the potential for unnecessary delays in treatment. Surgically creating ideal transfemoral residual limbs improves patient outcomes. Compliant documentation of healing, current health conditions and preparedness for prosthetic treatment is critical to support the prosthetic treatment plan. Understanding transfemoral socket designs, suspensions, knee joint and foot technology is required to develop the proper treatment plan and itemized prescription. Anticipated physiological residuum changes and functional improvements require prosthetic follow-up to maximize the fit and function of the prosthesis throughout the rehabilitation process. Ongoing surgeon follow-up versus early referral back to primary care or physical medicine and rehabilitation changes who sees and understands the patient’s long-term surgical and prosthetic outcomes. Surgical and prosthetic improvements in the future are made more exciting when paired with increased collaboration between the specialties.