New Methods to Lessen Blood Loss in TKA

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Although total knee arthroplasty is considered a very successful orthopedic procedure, management of perioperative blood loss remains a challenge. Newer techniques to improve blood loss include topical fibrin or thrombin-based sealants and use of systemic antifibrinolytic therapy. Evidence supports clinically significant improvement in blood loss with use of certain fibrin sealants and systemic administration of tranexamic acid. A thorough review of each of these classes of medication is presented to include mechanism of action, indications/contraindications, and available literature for use in total knee arthroplasty.

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