Bone marrow lesions (BMLs) are a recently identifiable cause of knee pain in patients with degenerative joint disease. BMLs are understood to be a stress reaction, bone defect, or fracture of the knee. A potential opportunity exists to healing and relief of patient symptoms through treatment of BMLs. In this report, we describe a method of treatment for these bone defects known as BMLs. Notwithstanding our promising results with this technique, further study is required to determine the most appropriate candidates who would benefit from this treatment.