The purpose of this review was to illustrate the role of nutrition in the prevention and management of peripheral arterial disease (PAD), which is one of the leading causes of disability in the United States. Declining physical function and loss of independence in the later years, which are potential consequences of this condition, highlight the importance of preventing or containing this disease. The risk factors for PAD are similar to those of coronary heart disease. The primary objective is to reduce the risk of cardiovascular morbidity and mortality. Optimal PAD management is best achieved by a combination of pharmacological intervention, lifestyle changes, and, when necessary, angioplasty or surgery. Addressing diet and eating is a critical component of a successful therapeutic approach. Improved nutrition is associated with a reduced prevalence of this disease. This article focuses on the role of nutrition as a component of lifestyle modification in the overall management of PAD.