An Improved Gas-Liquid Chromatographic Procedure for the Determination of Amitriptyline and Nortriptyline Levels in Plasma Using Nitrogen-Sensitive Detectors

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An improved gas-liquid chromatographic procedure for the plasma level determination of amitriptyline and nortriptyline using nitrogen-sensitive detectors is described. Derivatization of the secondary amines using trifluoroacetic anhydride greatly improves the response and reproducibility of the assay. Plasma samples containing as little as 5 ng/ml of amitriptyline and nortriptyline can be assayed precisely and reproducibly, using protriptyline as internal reference standard.

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