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Characterization of an Extracellular Proteolytic Signaling Pathway in Cancer
The intriguing side of the Hemostatic Balance
Structural aspects of urokinase-type plasminogen activator receptor (uPAR) function
Proteolytic pathways in cell death
Mass Spectrometry Driven Biological Discovery
Activity-based proteomics of proteases in human disease
CLIP-TAILS and CLIP-STEP
uPA and PAI-1
Tumor Microenvironment and Proteolysis
Proangiogenic Function of Plasminogen Activator Inhibitor-1 (PAI-1) in Angiogenesis
MONOCLONAL ANTIBODIES IN THE RATIONAL DESIGN OF PAI-1 MODULATING COMPOUNDS
PAI-1 and Vascular Pathology
Role of the fibrinolytic system in the development of obesity and the metabolic syndrome
Matrix metalloproteinases in brain injury, hemorrhage and remodeling after stroke
Matrix Protease Responses of the Neurovascular Unit During Ischemic Stroke
Neuroprotective mechanisms of activated protein C
Angiostatin4.5
Effects of PAI-1 on Endothelial Cell Signaling and Function
Distinct roles for cysteine cathepsins in multistage tumorigenesis
Thrombus Formation In Vivo
Dynamic imaging of protease location and function in ECM remodeling
In vivo Imaging of protease activity using fluorescent activity based probes
MATRIX REGULATION OF OVARIAN CANCE METASTASIS
MMP-9-dependent regulation of angiogenesis and invasion in GBM
Proteolytic Remodeling of the 3-Dimensional Extracellular Matrix
A Tale of Two Plasminogen Receptors
Urokinase Receptor-dependent Cell Signaling
Protease Signaling in Angiogenesis and Cancer
Engineered Human Proteases (Alterases) as a Broad New Therapeutic Modality
Plasmin
Microplasmin
Thrombosis and thrombolysis in host defense from microbial pathogens
Protein C
Protein C at the Crossroads of Coagulation and Inflammation
Membrane serine proteases and cell morphogenesis
The pro-uPA activator matriptase
MT1-MMP Controls Tumor-Induced Angiogenesis through Release of Semaphorin 4D
Tissue plasminogen activator and the interplay between neurons and microglia
Tissue Plasminogen Activator in Nervous System Function and Dysfunction
Control of Vascular Wall Integrity by LRP1
The role of the urokinase/urokinase receptor system in pulmonary immune and inflammatory responses.
Role of Tissue Factor, Coagulation Proteases and PARs in Inflammation
Multifunictional roles of plasmin in inflammation
The C-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth
Adenovirus Mediated Expression of Tissue Factor Pathway Inhibitor-2 Inhibits Endothelial Cell Migration and Angiogenesis
Novel peptide scaffold promotes cell migration and angiogenesis through enhanced expression of angiogenic factors
Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma
Effects of overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 on the malignant phenotype of ovarian cancer cells
Fibroblast Activation Protein Confers Enhanced Motility in a Fibroblast Derived 3D Matrix System
Synthesis and the biological activity of the phosphonic inhibitors of urokinase type plasminogen activator
CLINICAL SIGNIFICANCE AND CO-EXPRESSION OF KLK5 AND KLK7 IN BREAST CANCER
Cathepsins in Cancer
Estradiol inhibits EGF-induced mobilization of uPAR from detergent insoluble domains in ERa negative, GPR30 positive ovarian cancer cells.
An in vitro model for tumor cell - stromal cell crosstalk in ovarian cancer. Induction of uPA gene expression in stromal cells involves multiple signaling molecules, and is augmented by a 3D extra-cellular matrix.
Tumor Cell Signaling Through Integrin alpha5beta1 Requires Urokinase Receptor Binding
Gene and protein expression profiling of human MMPs and TIMPs in primary tumors derived from high and low disseminating variants of HT-1080 fibrosarcoma
The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals.
Distinct alterations in the expression levels of SRA1 gene, in the breast cancer cell line MCF7, as a response to treatment with anticancer drugs.
Real-time PCR analysis of BCL2L12, a novel member of BCL2 family of the apoptosis-related genes, in human leukemia.
Kallikrein-related (KLK) serine proteases and their roles in prostate cancer
Japanese guidelines for pulmonary thromboembolism (PTE) prophylaxis is effective for a decrease in the occurrence of PTE
Quantification of soluble fibrin and D-dimer at the pregnancy with the risk of fetal loss
The repeatability of quantitative D-Dimer assays in clinical laboratories.
Fibrin degradation by various enzymes
Products of limited elastase/cathepsin G degradation of fibrinogen as new biomarker in cardiovascular disease.
Treatment with tranexamic acid (TA) of patients with mild bleeding disorders
Antibodies to tissue-type plasminogen activator (t-PA) in patients with inflammatory bowel disease
The clinical significance of hyperfibrinolysis in onset of disseminated intravascular coagulation syndrome
Effect of APC resistance associated with factor V mutations on plasma fibrinolysis
Performance of a new rapid quantitative D-dimer assay (HemosIL D-dimer Plus) in the diagnosis of pulmonary embolism. Comparison with other quantitative assays. Preliminary results.
Homogeneous, Bioluminescent Assays for Proteasome Activity and Other Protease Therapeutic Targets
Non-invasive, optical imaging of specific cell surface proteolytic activity in single living cells
Biochemical predictors of total mortality in unselected acute coronary syndromes patients treated according to contemporary guidelines - time-dependent change in prognostic value
Lipoprotein(a) can alter fibrin clot permeability and susceptibility to lysis in vivo
HOMOCYSTEINYLATION OF HUMAN FIBRINOGEN LEADS TO FORMATION OF FIBRINOGEN-ALBUMIN CONJUGATES AND INCREASED RESISTANCE TO FIBRINOLYSIS
Delaying Fibrinolysis with Synthetic Peptides Patterned on Fibrin B Knobs
Plasma Fibrinogen Gamma Prime Chain Content in the Thrombotic Microangiopathy Syndrome
Identification of fibrinogen binding site of human histidine-rich glycoprotein (HRG)
IDENTIFICATION OF RESIDUES OF ALPHA-CHAIN OF FIBRIN IMPLICATED IN THE BINDING OF ACTIVATED FXIII A SUBUNIT
The role of fibrinogen in a murine model of lethal endotoxemia
Fibrinogen deficiency and LDL driven atherosclerosis in mice
Proteolytic Regulation of Activated Coagulation Factor XIII by Plasmin
IDENTIFICATION OF NOVEL BINDING INTERACTIONS BETWEEN FACTOR XIII AND BOTH TISSUE PLASMINOGEN ACTIVATOR AND PLASMINOGEN
SITE-DIRECTED MUTAGENESIS OF RESIDUES SURROUNDING THE THROMBIN CLEAVAGE SITE IN FACTOR XIII-A SUBUNIT DEMONSTRATES RELEVANT SITES FOR INTERACTION
Thrombin upregulates expression of oncostatin M (OSM) in human macrophages and peripheral blood monocytes.
Transgenic Evidence For The Concentration of t-PA Expressing Sympathetic Nerves in Arterioles
Regulation of Urokinase Receptor Expression by Protein Tyrosine Phosphatases
No Evidence for an Association of the Tissue-type Plasminogen Activator -7351C/T Enhancer Polymorphism and the Presence of Stable Coronary Artery Disease or the Occurrence of Acute Myocardial Infarction
Plasminogen binding on the surface of Leishmania mexicana by enolase
The maintenance of high affinity plasminogen binding by PAM variants from group A streptococci is mediated by both a1 and a2 repeat domains and is not dependent on lysine residues
In situ assays reveal mechanisms by which immunity regulates protective fibrin deposition during infection.
Mice expressing a thrombin variant engineered to favor anticoagulant function are resistant to S. aureus-induced sepsis
ORGAN-SPECIFIC EXPRESSION OF THE PLASMINOGEN ACTIVATING SYSTEM IN A BABOON MODEL OF SEPSIS
von Willebrand Factor Binding Protein is a Novel Conformational Activator of Prothrombin that Functions Through a Substrate-assisted Molecular Sexuality Mechanism
Minor Edema Formation after DSPA-induced Clot Lysis of Experimental Intracerebral Hemorrhages
The Role of Endogenous versus Exogenous tPA on Edema Formation in Murine ICH
Elevation of complement C3 and C-reactive protein in men with myocardial infarction
Distinct Engagement of Integrin alphaMbeta2 by Plasminogen and Angiostatin Controls Neutrophil Apoptosis.
Matriptase is the essential target of hepatocyte growth factor activator inhibitor-1 during embryonic development
BIOCHEMICAL CHARACTERIZATION OF PROSTASIN, THE EPITHELIAL SODIUM CHANNEL ACTIVATING PROTEASE
Tetraspanin associations with membrane type-1 matrix metalloproteinase (MT1-MMP)
Inhibitory Effects of Green Tea Catechins and Lignans on the Activity of Human Matrix Metalloproteinase 7 (MMP-7) and Insights into Their Structure-Activity Relationship
The induction of matrix metalloproteinases by endotoxin in vivo is modulated by short term simvastatin-treatment
HIGH MMP-9/NGAL COMPLEX LEVELS IN GASTRIC CANCER TISSUE ARE ASSOCIATED WITH WORSE SURVIVAL
MATRIX METALLOPROTEINASES AND THEIR INHIBITORS IN GASTRIC CANCER
INFLIXIMAB INDUCES A GENOTYPE-DEPENDENT MUCOSA PROTECTIVE MATRIX METALLOPROTEINASE PHENOTYPE IN INFLAMMATORY BOWEL DISEASE
Terminal sialylation regulates autolysis of cell surface-associated membrane type-1 matrix metalloproteinase (MT1-MMP)
Endogenous Upregulation of tPA Contributes To Histopathology After Cerebral Hypoxia/Ischemia In The Newborn Through LRP and ERK MAPK.
Loss of p75 neurotrophin receptor exacerbates the effects of plasminogen deficiency
Fibrin/Mac-1 interactions induce microglia activation and regulate relapsing paralysis in central nervous system autoimmune disease
Fibrin deposition and axonal damage in spinal cord injury
The tissue-type plasminogen activator/plasminogen system induces alterations in cortical neuron organization and survival
Neutralizing the neurotoxic effects of exogenous and endogenous tPA
Tissue-Type Plasminogen Activator-Plasmin Cascade in Experience-Dependent Plasticity of Visual Cortex
Regulation of tPA and PAI-1 gene expression in human astrocytes
Tissue-type plasminogen activator can promote NMDA-induced neuronal stimulation via LDL receptor and plasmin-dependent mechanisms.
Unconventional translation initiation of trypsinogen 4 at a CUG codon with an N-terminal leucine
Recurrent stroke due to intra-luminal carotid thrombus in a patient with active multiple myeloma
p75 Neurotrophin Receptor Regulates Fibrinolysis via a cAMP/PKA Pathway
Plasminogen Activator is Necessary for Spinal Cord Synaptic Plasticity
Development and Characterization of a Murine Model of Thrombotic Stroke
MODULATION OF NEUROTRANSMITTER RELEASE FROM CATECHOLAMINERGIC CELLS BY THE BINDING OF PLASMINOGEN TO CELL SURFACE ACTIN FORMS
Role of the Plasminogen Activation System in Hippocampal Neuritogenesis
Beyond proteomics
LRP and avb3 integrin mediate tPA-activation of smooth muscle cells.
Purification and characterization of ancistron-Bu, a novel fibrinogen-clotting serine protease from Agkistrodon blomhoffii ussuriensis venom
Inhibition of an Aspartyl Protease
Application of In Vivo Labeling of Cysteine Cathepsin Protease activities
The interaction of active-site blocked thrombin and bivalirudin
Overexpression of TIMP-1 in mice does not affect adipogenesis or adipose tissue development
Impaired adipose tissue development in mice with inactivation of placental growth factor function
Elevated prothrombin level and shortened clotting times in subjects with type 2 diabetes
Cathepsin S Expression in Mouse Obesity Models
Keratinocyte-derived chemokine in adipocyte biology and obesity
The 4G Genotype Plasminogen Activator Inhibitor - I (PAI-I) is associated with Deep Vein Thrombosis in Saudis.
Hepatocyte Growth Factor Induces Plasminogen Activator Inhibitor Type 1 Gene Expression in Human Hepatocytes in an E Box-Dependent Manner
Murine plasminogen activator inhibitor-1 (PAI-1) does not affect adipogenesis or adipocyte differentiation
PLASMINOGEN ACTIVATOR INHIBITOR-1 PLASMA LEVELS ARE ASSOCIATED WITH CORONARY INSTENT RESTENOSIS OF DRUG ELUTING STENTS
Elucidation of the molecular interaction mechanism between PAI-1 and a PAI-1 inhibiting antibody fragment Fab-55F4C12
The epitope of MA-31C9, a non-inhibitory anti-PAI-1 antibody, overlaps with the epitope of a previously identified inhibitory antibody
Analysis of blood platelet plasminogen activator inhibitor under treatment by streptokinase
Plasminogen activator inhibitor 1 forms a stable non-acyl enzyme inhibitor complex with tissue plasminogen activator
S-35225 decreases plasma PAI-1 activity both in vitro and in vivo
Efficacy of PAI-749, an orally active PAI-1 inhibitor, in dog and rat models of arterial and venous thrombosis
Effect of plasminogen activator inhibitor-1 on growth of mouse melanoma cells
Mechanistic Studies on the Inactivation of Plasminogen Activator Inhibitor (PAI-1) by PAI-749, a Small Molecule PAI-1 Antagonist
Rational design of cysteine mutants of PAI-1 with very long half-lives
Expression and purification of cysteine mutants of PAI-1 with very long half-lives
ROLE OF PLASMINOGEN ACTIVATOR INHIBITOR-1 AND UROKINASE IN EARLY STAGES OF ATHEROGENESIS IN KNOCKOUT MICE
Vitronectin accelerates protease inhibition by PAI-1 through its cryptic protease binding site
PAI-1 modulates the inflammatory response during Lipopolysaccharide (LPS)-induced endotoxemia.
Defining the Second Site for Interaction of PAI-1 and Vitronectin
High PAI-1 and the malignant phenotype
PLAP/IRAP defficiency attenuates hypofibrinolysis in mice thrombosis models
APC and duodenase can control an inflammation via the PARs on mast cells
Regulation of cancer cell plasmin generation by annexin A2-S100A10 heterotetramer (AIIt)
Plasminogen receptors on macrophages
Requirement of Matrix Metalloproteinase-9 Activation in Plasminogen-regulated Macrophage Recruitment
An antibody anti-alpha-enolase, MAb 11G1, inhibits myogenesis in vitro and in vivo
The Effects of a PAM-derived Peptide on the Structure and Zymogenicity of Plasminogen
The annexin A2 heterotetramer is a receptor for the plasmin-induced signaling in human peripheral monocytes activated by proteolytic cleavage
Molecular requirements for modulation of NMDA receptor signaling by tissue-type plasminogen activator
Substrate profiling of the Clan CE proteases
Urokinase signalling through its receptor protects against anoikis by increasing Bcl-xL expression levels
Urokinase receptor activation by a novel interaction between connecting peptide region of urokinase and alphavbeta5 integrin
Serine proteases as initiators of intracellular signalling.
The metastasome defines lynchpin uPAR-driven protein
Activation of Glu-, Lys- and mini-plasminogen by equimolar quantities of streptokinase 36 kDa fragment and effect of fibrin on this process
The Effects of Oral Contraceptives on Plasma - Studied by Proteomics.
Investigation of Novel Serine Protease Activity in Apoptotic Regulation
Activity Based Protein Profiling of HT-1080 Variants Identifies uPA Activation as a Key Regulator of Tumor Cell Intravasation
Effect of alpha-2-antiplasmin on activation of plasminogen by different activators and following fibrin lysis
A Novel ELISA for Mouse Activated Protein C in Plasma Based on Interspecies Inhibition by Human Protein C Inhibitor
A structural basis for differential cell signaling initiated by PAI-1 and PAI-2
Assessment of known/potential binding sites in the PAI-2 CD-loop for interaction with annexin II and endocytosis receptors
Phosphatidylserine and oxidized phosphatidylethanolamine interact with Protein C Inhibitor (PCI) and modify its activity
Interactions between Urokinase-Type Plasminogen Activator and Its Receptor Defined by the X-ray Crystallography
Biochemical characterization of derivatives of MA-T12D11, a TAFI neutralizing antibody
Fibrinolytic efficacy of Amediplase, Tenecteplase and scu-PA in different external plasma clot lysis models. Sensitivity to the inhibitory action of thrombin activatable fibrinolysis inhibitor (TAFI).
The Thr325Ile polymorphism and intrinsic enzymatic activity of proCPU (TAFI)
An increased risk of ischemic stroke is related to activated TAFI levels but not to genetic variation
A stable TAFIa variant as a tool to study TAFIa destabilization
MA-T18A8, the first monoclonal antibody directed towards a neoantigenic epitope in activated TAFI
Generation and characterization of monoclonal antibodies directed towards rat TAFI
Binding of TAFI to collagen
Development of a sandwich-type ELISA for the detection of Rat TAFI
A Computer Model of the Fibrinolytic Cascade and its use to Investigate the Inhibition of Fibrinolysis by TAFIa.
The Kinetics of Glu- and Lys-Plasminogen Activation on Untreated and TAFIa Treated High Molecular Weight Fibrin Degradation Products
A Kinetic Analysis of the Conversion from Glu-plasminogen to Lys-plasminogen by Plasmin in the Presence of Soluble High Molecular Weight Fibrin Degradation Products and the effect of TAFIa on this reaction
Prognostic value of TAFI level in patients with liver cirrhosis
The Intrinsic Antifibrinolytic Effect of Carboxypeptidase N is Attenuated by an Inhibitory Component(s) in Plasma
Characterization of the 48kDa Active Subunit of Carboxypeptidase N and Determination of its Anti-Fibrinolytic Potential
In situ clot formation
Anti-platelet aggregation and anti-Helicobacter pylori activity of dipicolinic acid contained in Bacillus subtilis natto
Regulation of tPA activation and inhibition kinetics by fibrin and fibrinogen
Computer models of fibrinolysis
Inhibition of Various Plasmin Species by Plasma Inhibitors and Its Effect on Clot Lysis
Heritability of plasma D-dimer, clot turbidity and clot lysis in the Leeds Family Study
Evidence for an enhanced fibrinolytic capacity in cirrhosis measured with a new global fibrinolysis test in whole blood.
Effect of essential oils on the plasma coagulation and fibrinolysis systems
The streptokinase's 7 kDa fragment – a possible regulation factor of the fibrinolytic system
In vitro effects of two new drugs, Bivalirudin and Desmoteplase, on clot lysis. A comparison with drugs currently used in thrombolysis and revascularisation
Induction of uPA, IL-8 and early growth response-1 by imatinib through activating MAPK in human small cell lung cancer cells
Structural basis of uPAR-uPA and uPAR-vitronectin interactions
Nuclear translocation of urokinase-type plasminogen activator
One-step affinity purification of recombinant uPAR using a synthetic peptide
Cleavage of uPAR; mechanism and prognostic significance.
Generation and characterization of murine monoclonal antibodies against murine uPAR
Inhibition of mouse uPA activity by mouse monoclonal antibodies
The Role of uPAR and Alpha 3-Beta 1 Integrin in the Modulation of Integrin Function
Macrophage-Expressed Urokinase-type Plasminogen Activator is an Important Modifier of Atherosclerosis
Initial Angiogenic Cell Migration Depends on CD87-D3 Mediated Integrin Internalization
Urokinase (uPA) induces cell survival by up-regulating inhibitor of apoptosis proteins (IAPs)
The density enhanced phosphatase 1 (DEP-1) down-modulates urokinase receptor (uPAR) surface expression in confluent endothelial cells
Mechanisms of Urokinase-Mediated Vasoconstriction
Macrophage-Expressed Urokinase-Type Plasminogen Activator Accelerates Atherosclerosis Progression in Two Mouse Models
The plasminogen activation system and skeletal muscle regeneration
Bone Marrow-derived PAI-1 Influences the Development of Obesity
Effect of ochratoxin A on tissue factor and PAI-2 production by human blood mononuclear cells
Lipoprotein(a) Isoform Size Heterogeneity