Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer
PAI-1 induces malignant phenotype modulating expression and activity of MAPK pathway regulator dual activity phosphatases (DUSP)
In vivo inhibition of the murine uPA-uPAR interaction and selective identification of muPAR variants on cells using monoclonal antibodies raised in uPAR deficient mice
The expression pattern of the urokinase plasminogen activation system in human colon cancer is recapitulated in liver metastases with desmoplastic encapsulation
The effects of TAFIa on Glu-and Lys-Pg activation and on fibrin modulation of plasmin inhibition by antiplasmin
Platelets enhance fibrinolysis by single-chain urokinase activation
Intravascular thrombosis in transgenic mice whose non-thrombin-binding gamma'chain fibrinogen sequence has been replaced by the human thrombin-binding gamma' sequence
Neuron microparticles
The role of thymosin β4 in the proteolytic properties of migrating endothelial cells
Differential effect of acute and chronic hypoxia on human endothelial cells with regard to pericellular proteolysis (uPA, uPAR) and fibrinolysis (tPA and PAI-1)
Discovery of a novel transmembrane plasminogen receptor using multidimensional protein identification technology
Evidence for beta-hairpin swapping as a possible mechanism of alfaC-polymer formation in fibrin
Cleavage of residues 1–42 from the Bbeta chain of fibrinogen results in defective fibrin oligomer formation and reduced clot stiffness
C1-inhibitor (C1INH) prevents non-specific plasminogen activation by a mutant (M5) of prourokinase (proUK) even at the optimal fibrinolysis rate of a plasminogen activator
Probing the relative importance of tPA finger and kringle binding to fibrin for plasminogen activation and fibrinolysis
Clinical use of cleaved forms of the urokinase receptor
The interaction between tissue-type plasminogen activator (tPA) and the low density lipoprotein receptor-related protein (LRP) induces Akt phosphorylation in the neurovascular unit during cerebral ischemia
Urokinase plasminogen activator (uPA) and atherosclerosis
Identification of JFC1 as intracellular partner for protein C inhibitor (PCI)
Factor XII is a novel mitogenic factor for alveolar type II cells in pulmonary fibrosis
Enolase-1 promotes invasion of monocytes into the alveolar space of the acutely inflamed lung
Potentiation of MCP-1-mediated chemotaxis by plasmin
Vascular endothelial growth factor (VEGF)-induced initial endothelial cell migration requires urokinase receptor (uPAR) for integrin redistribution
An endothelial cell-associated deficiency of urokinase-plasminogen activator receptor alters cell morphology and angiogenic function in a vitronectin-dependent manner
Cell-specific deletion of VEGF-R2/flk-1 results in a failure of thrombus resolution
Effects of low density lipoproteins on the sub-cellular distribution pattern of UPA/UPAR in migrating human coronary vascular smooth muscle cells
Half dose reteplase plus abciximab in STEMI patients
A new thromboembolic stroke model in the anaesthetized mouse
A pilot trial of microplasmin in patients with long-term venous access catheter thrombosis
Thromboembolic ischaemia and immunotherapy
Thrombolytic therapy of a large right-ventricular thrombus and pulmonary emboli in a 24-year old female as the first manifestation of an antiphospholipid syndrome
Tissue factor pathway inhibitor relates to fibrin degradation in patients with acute deep venous thrombosis
Role of kringl-domains of Glu-plasminogen (Glu-Pg) in its activation by staphylokinase (STA)
Generation of plasmin via a proteolytic cross-talk mechanism between matrix-bound plasminogen and uPA expressed by cellular microparticles or monocytes
Interplay of human kallikrein-related peptidases (KLKs) with the tumor-associated urokinase/plasmin system
The kallikrein-kinin system, but not coagulation, is activated by interaction of FXII with misfolded proteins
Role of uPA in excessive fibrinolysis observed in AL-amyroidosis
Effect of defibrotide on plasmin activity Echart C
Alpha-enolase is a mediator of plasminogen-induced intracellular signalling in myogenic cells
The expression of urokinase type-plasminogen activator by c-Myc on hypoxia-induced vascular smooth muscle cells
Effect of statins on t-PA and PAI-1 expression by cultured endothelial cells. Role of Rho proteins and MAP kinases
Urokinase (uPA) induces endothelial cell survival via the X-linked inhibitor of apoptosis protein (XIAP)
The expression of PAI-1, tPA and uPA is strongly regulated during differentiation of mouse embryonic stem cells towards the myogenic and adipogenic lineages
Local metalloproteinase-9 expression and activity is reduced by LDL internalization in human coronary smooth muscle cells
Distinct roles of plasmin in Staphylococcus aureus-induced sepsis and infection models
Echinococcus multilocularis depends on the host fibrinolytic system
Plasminogen enhances the healing of tympanic membrane perforations
Human plasminogen and Group A Streptococcal M-like protein
Requirement of heat shock factor-1 for modified LDL-induced production of plasminogen activator inhibitor-1 in cultured vascular cells and knockout models
Ku80 as a novel receptor for thymosin ß4 that mediates its intracellular activity to upregulate PAI-1 expression in endothelial cells
Heterogeneous glycosylation patterns of human PAI-1 may reveal its cellular origin
HIF-2alpha mediated regulation of PAI-1 in VHL-associated renal cell carcinoma
Anti-mullerian hormone (AMH)-dependent regulation of the brain serine protease inhibitor, neuroserpin
Incorporation of alpha2-antiplasmin into fibrinogen by plasma factor XIII
Auto-regulation through local protein dynamics revealed by crystal structures of TAFI
Presence of TAFI ameliorates obstructive nephropathy
TAFI zymogen does not play a role in the attenuation of fibrinolysis
A study of the roles of selected arginine and lysine residues of TAFI in its activation to TAFIa by the thrombin-thrombomodulin complex
TAFI activation peptide shows association with 2-year outcome after ischemic stroke
Carboxypeptidase U (TAFIa) is induced in vivo during thrombolytic therapy in ischemic stroke patients and decreases the thrombolytic efficacy
Factor VII-activating protease in patients with deep venous thrombosis - no reduction in scu-PA activating properties
Mild hyperhomocysteinemia is associated with impaired plasma fibrinolysis
Hypofibrinolysis as risk factor for arterial thrombosis
Clopidogrel pretreatment abolishes increase of PAI-1 after coronary stent implantation
Increased elastase degradation products of fibrinogen in stroke patients
Presynaptic depolarization prevents tPA-dependent extrasynaptic neurotoxicity
HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival
Injured neurons bind t-PA and plasminogen via different mechanisms and promote plasmin formation
Activated protein C can protect the rat cortical and hippocampal neurons from glutamate-induced death
T lymphocytes regulate cytokine synthesis in human adipocytes. Participation of the CD40/CD40L pathway
Functional role of gelatinase A (MMP-2) in development of nutritionally induced obesity in mice
Adipomin, a fibrinolytic factor found in adipose tissues, regulates proliferation and apoptosis of adipocytes
Metabolic and hormonal regulation of plasminogen activator inhibitor-1 gene expression
Effect of murine plasminogen activator inhibitor-1 (PAI-1) on de novo preadipocyte differentiation in vivo
Hypoxia mediates the inflammation in human adipose tissue
Test-systems for estimating the biological activities of angiostatin-like plasminogen fragments in vitro
The influence of fibrin structure on plasminogen activation and fibrinolysis
The overall haemostatic potential (OHP)
Utility of a global assay, the overall haemostatic potential (OHP), for measuring fibrinolysis in hypercoagulable states
The effects of aspirin on fibrin clot structure using a novel cellular in vitro system
A computer model of the fibrinolytic cascade and the use of it to elucidate global functional properties of the fibrinolytic system
Role of the kringle 2 domain of tissue-type plasminogen activator (tPA) in the design of a new generation of thrombolytic agents for treatment of acute ischaemic stroke
Construction and characterization of nanobodies generated against TAFI
Characterization of a fusion protein with combined erythrocyte binding properties and activation fibrinolytic activity within nascent and pathological clots
Tiplaxtinin inhibits PAI-1 production by different cell types
Discovery of novel mechanisms and molecular targets for the inhibition of TAFIa
In vitro evaluation of thrombolytic efficacy of plasmin and other direct thrombolytic agents
Assesments of relation between Iranian holiday and myocardial infarction's complications who referred to Rasool Akram Hospital in 2001–2007
A comparative study of D-Dimer levels using innovance D-Dimer and D-Dimer PLUS in different stages of pregnancy with establishment of a reference range for Australian women
Low-molecular-weight heparin treatment failure in a patient with prosthetic mitral valve
Activated TAFI levels are associated with the risk of cardiovascular death in patients with coronary artery disease
Factor XIII levels in patients with different stages of alcoholic liver cirrhosis
Plasminogen activator inhibitor 1 (PAI-1) in essential thrombocythemia patients
Endothelial prothrombotic and fibrinolytic factors in patients with heart failure
Heart valve surgery
Local complement activation is involved in leukocyte recruitment to the site of atherosclerotic plaque rupture in acute myocardial infarction
Fibrinolysis, Plasminogen activator inhibitor-1 and levels of sex hormone binding globulin in young women
Elastase degradation products of fibrinogen and venous thromboembolism
A common polymorphism at the C-terminal of the fibrinogen beta chain results in altered fibrinolysis
Activated protein C accelerates ulcer healing in rats
Platelet active components from Agkistrodon blomhoffii ussuriensis snake venom
The regulation of factor XIII (FXIII) by human neutrophil proteases within the fibrin clot
Mechanical strength of fibrin fibers branching points
Fibrinogen interacts with histidine-rich glycoprotein (HRG) at the multiple sites
Urokinase plasminogen activator receptor (uPAR) expression in gastric carcinomas from high and low risk countries
Inhibition of receptor-bound urokinase in cancer
Proteolytic patterns in adenocarcinomas of the lower esophagus and upper gastric mucosa
Nafamostat mesilate (FUT-175) inhibits cell growth and cell invasiveness in human malignant mesothelioma cell
Significance of plasminogen activator inhibitor type 1 and its gene polymorphism in colorectal carcinoma patients
Cleaved forms of the urokinase plasminogen activator receptor in plasma enhance discrimination of benign from malignant disease and predict survival in patients with ovarian cancer.
Nucleolin-Stati signaling complex mediates monocyte differentiation
Tumor suppressor KAI1 (CD82) crosstalks with integrin avβ3 and alters ovarian cancer cell adhesion, motility, and proliferation
APC anti-inflammatory effect on mast cells
LPS-Stimulated monocytes inhibit fibrinolysis through a tissue factor (TF) - and TAFI-mediated mechanism and attenuate the profibrinolytic activity of heparins
The tight junction protein ZO-2 mediates spreading and adhesion of human vascular smooth muscle cells
Tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) affects angiogenesis during adipocyte differentiation in vivo
Tissue-type plasminogen activator storage and secretion from human astrocytes
Hydroxytyrosol suppresses phorbol ester-induced matrix metalloproteinase (MMP)-9 expression by inhibiting both PKC-1 and NF-kB activation in human monocytoid cells
Unique exocytotic dynamics of tissue plasminogen activator (tPA) from vascular endothelial cells (VECs) and its modification by PAI-1
Growth-related regulation of TAFI expression and its role in hepatocyte proliferation
VEGF-induced rapid mobilization of c-kit/sca-1 positive murine bone marrow cells is impaired in urokinase (uPA) and in urokinase receptor (uPAR) deficient mice
Activity of fibrinolytic system (FS) components and angiotensin converting enzyme (ACE) in various tissues of rabbit eyes before and after cornea burn
Interference of the inhibitors of renin-angiotensin system (RAS) and fibrinolytic system (FS) on their key enzymes in vitro
Specific targeting of uPA activity with a monoclonal antibody neutralizes uPA-dependent effects in vivo
Enzyme specificity and kinin-releasing activity of nattokinase
Diet supplementation with oregano or rosemary increases plasminogen activator activity in healthy rat brain
Implication of the plasminogen activation system in carbon tetrachloride (CCI4)-induced oxidative stress in rat brain. Antioxidant effect of long-term dietary administration of oregano or rosemary
Glycation of thrombin-activatable fibrinolysis inhibitor (TAFI) results in loss of its fibrinolytic function
Investigating stimulation of plasminogen activation by fibrinogen using domain variants of tPA
Ligand recognition specificity of the novel plasminogen receptor, Plg-RKT
Heated natto and nattokinase found to have significant activity of t-PA releasing from human cells
Analytical performance of a new D-dimer assay, Innovance® D-DIMER*
Contamination of commercial sources of fibrinogen by carboxypeptidase N
Detection of hypofibrinolysis by thrombelastography
Evaluation of aspirin response using Multiplate® whole blood aggregometry
Is the VerifyNow® Aspirin Assay able to identify aspirin resistance using the recommended cut-off?
Low-dose aspirin inhibits serum thromboxane B2 more than 99 percent
Point-of-care platelet function tests in clopidogrel-treated patients requiring urgent cardiovascular surgery
Computational & experimental investigation of the plasmin activation system