Identification of a protein factor that regulates human thrombin-activatable fibrinolysis inhibitor mRNA stability
Effect of TAFIa inhibition on tissue factor-induced thromboembolism in the mouse
Evaluation of the profibrinolytic properties of an anti-TAFI monoclonal antibody in a mouse pulmonary embolism model
Novel in vivo and in vitro profibrinolytic effect of MMP-10 mediated by TAFI
Intact thrombomodulin-mediated regulation of fibrinolysis during and after liver transplantation, despite a profoundly defective thrombomodulinmediated regulation of coagulation
Soluble thrombomodulin improves the hemostatic balance in whole blood from canines with hemophilia A
Tissue-type plasminogen activator (t-PA) and tenecteplase but not urokinase or desmoteplase modulate permeability across a human model of the blood-brain-barrier
Tissue-type plasminogen activator (t-PA) induces intracranial bleeding through stromelysin-1 (MMP-3) induction in endothelial cells via low-density lipoprotein receptor family
Hypoxia and upregulation of hypoxia inducible factor 1 alpha stimulate angiogenesis within resolving venous thrombi
Deficiency of thrombospondin-2 does not affect murine adipose tissue angiogenesis or development
Polymerization of serine protease inhibitors is critically dependent on structural stability of deeply buried residues inside surface cavities
The urokinase receptor: from structure-function relationships to in vivo imaging
Clinical relevance of fibrin structure for coagulation and fibrinolysis
Role of fibrin clot structure in susceptibility to lysis
Effects of total fibrinogen and fibrinogen γ' on thrombin generation in plasma
Clots formed from γ'-fibrinogen are resistant to lysis because of impaired plasminogen activation by t-PA
Hampered dissolution of fibrin formed under mechanical stress
Composition of coronary thrombi in acute myocardial infarction
Fibrinolysis and innate immunity
The occupancy of EPCR by protein C switches the PAR-1-dependent proinflammatory function of thrombin to a protective response
The human fibrinolytic system is a target for proteases secreted by the pathogenic bacterium Pseudomonas aeruginosa
Fibrinolysis impairs host defense during severe murine gram-negative sepsis (melioidosis)
Caveolin deficiency leads to increased activation of coagulation and decreased fibrinolysis in mice
Introduction: bleeding and thromboelastography
The clinical problem and trials with fibrinogen
The effect of blood plasma substitutes on fibrin structure
Thrombelastography-based monitoring for massive blood loss in children during elective surgery for craniosynostosis repair, TEG®versus ROTEM®
Fibrinogen and post-partum hemorrhage: from prediction to treatment
Update on the clinical relevance of the plasminogen activation system in cancer
Extracts of echinococcus multilocularis cysts induce proliferation and protease expression of human umbilical vein endothelial cells in vitro
Modulation of uPAR signaling to ERK/MAPK by endocytic receptors of the LDLR family
uPAR/LDLR interaction: a novel target for efficient endothelial cell migration
Growth factor induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution
Characterization of breast cancer cell lines overexpressing the urokinase receptor splice variant uPAR-del4/5 or the GTP binding protein rab31
Matriptase induces formation of skin carcinoma through activation of hepatocyte growth factordependent signaling pathway
Polyphosphate modulates fibrin structure altering its susceptibility to lysis
Fibrin structure and the regulation of tissue plasminogen activator (tPA) binding and potency
Intra-vital analyses of plasminogen binding to platelet-rich micro-thrombus
Fibrinolysis regulation: Interaction of a2-antiplasmin with fibrin(ogen) and localization of the binding sites
Synthetic nonadecapeptide (SAK22-40) enhances plasminogen activation and thrombolysis
Stable and reversible fusion protein conjugated to red blood cells for drug delivery in thromboprophylaxis
Highly sensitive ELISA method for the determination of alpha2-plasmin inhibitor antigen level
The influence of alpha2-antiplasmin polymorphism Arg407Lys on fibrinolysis
The adipokine vaspin inhibits smooth muscle migration in vitro and the development of coronary in-stent restenosis in vivo
PAI-1 as a furin convertase inhibitor: a potential role in insulin resistance
Metals exert an unexpected role in regulating enzymes in the plasminogen activation cascade
Evaluation of a panel of plasminogen activator inhibitor-1 inhibiting monoclonal antibodies in a mouse pulmonary embolism model
The biochemistry of TAFI
Haemostasis and innate immunity
Allosteric activation of the DegS protease: design principles of stress-sensor proteases
TAFI regulates hepatocyte survival during liver regeneration independent from cell-associated plasminogen
Binding characteristics of thrombin-activatable fibrinolysis inhibitor to streptococcal surface collagen-like proteins A and B
Staphylococcus aureus clumping factor A is a causative virulence factor in experimental murine sepsis
3D virtual histology using MR-T1 mapping to quantify venous thrombus organisation
D-dimer: the lack of comparability of test results and possibilities for harmonization
Performance of the Vidas D-dimer assay to rule out venous thromboembolism across age categories in 1004 consecutive out-patients
Different cut-off values of quantitative D-dimer (DD) assays to establish duration of oral anticoagulation treatment (OAT) after venous thromboembolism (VTE)
Inflammatory and thrombotic markers in patients with ST-elevation myocardial infarction treated with fibrinolysis and early PCI
Tissue plasminogen activator, fibrin D-dimer and Von Willebrand factor antigens and risk of future coronary heart disease
Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men
Regulation of cell surface proteolysis and cell migration by the novel plasminogen receptor, Plg-RKT
The novel plasminogen receptor, Plg-RKT, regulates catecholaminergic function
Effect of histone deacetylase inhibitors on tissue-type plasminogen activator expression in human endothelial cells
Allelic imbalance of tissue-type plasminogen activator (tPA) gene expression in human brain tissue
Identification of proteins that selectively misfold within the acutely injured brain and accelerate tPA-mediated plasmin formation: implications for ischemic stroke
New functions of t-PA and factor XII in amyloid and protein metabolism
Engineering Kunitz 1 domain (KD1) of human tissue factor pathway inhibitor-2 to selectively inhibit fibrinolysis: properties of KD1-L17R variant
Plasminogen deficiency in mice causes periodontal disease
Biological variation in tPA-induced plasma clot lysis time
Plasma fibrinolytic capacity and the risk of arterial thrombosis in young women
Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1
Clot lysis time (CLT) of PRP and PPP in hypercholesterolemia. Effect of atorvastatin and relationships with inflammatory markers
Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis
Two cases of dysfibrinogenemia associated with thrombosis
Biologically active human fibrinogen produced in the milk of transgenic cows
The density of surface bound fibrinogen effects the release of fibrinopeptides
New evidence for fibrinogen-bound alpha2-antiplasmin in blood
Early factor XIII activation and delayed fibrinolysis in individuals with Factor V Leiden; a novel mechanism contributing to increased thrombosis risk
Global health risk associated with the use of recombinant streptokinase as a biosimilar for thrombolytic therapy
ISFP Prize Lecture 2010. From PAI-1 to PDGF in the brain, a series of fortunate events
Clinical value of D-dimer testing
Carboxypeptidase U (TAFIa): a new drug target for fibrinolytic therapy?
The role of activation peptide residues Lys42, Lys43, and Lys44 of TAFI in its activation by the thrombin-thrombomodulin complex
Identification and characterization of monoclonal antibodies that impair the activation of human TAFI through different mechanisms
The role of TAFI and Factor XI in platelet-mediated resistance to fibrinolysis
Internalization of thrombin-activatable fibrinolysis inhibitor in keratinocytes by receptor-mediated endocytosis
Antibodies based immunotherapy for stroke
Role of tPA in the rewarding effect of abused drugs
MMP-10: a new fibrinolytic agent in ischemic stroke?
Roles of urokinase receptor (uPAR) on ischemic stroke
Clinical thrombolysis
Optimizing thrombolytic efficacy and safety by preventing non-specific plasminogen activation
Exploring the sensitivity of fibrinolysis rates to inhibition of tissue plasminogen activator (tPA)-fibrin binding and plasminogen-fibrin binding
A multi-scale mathematical model of fibrinolysis: from fiber cross sections to whole clots
Lysis of thrombi formed in the Chandler loop or Badimon chamber
Tissue Remodeling and Matrix Metalloproteinases
Plasminogen-dependent mobilization of hematopoietic stem cells-induced by G-CSF requires two independent pathways, activation of MMP-9 and SDF-1/CXCR-4 regulation
Activated protein C prevents neuronal apoptosis at excitotoxicity via inhibition of p53
Tissue-type plasminogen activator (tPA) and plasmin(ogen) participate in the removal of dead cells
Plasminogen as a novel therapeutic agent to treat tympanic membrane perforations
An in silico model for haemostasis: computational methods and algorithms
Global fibrinolysis assays
Cell culture technology and stem cells in research: emphasis on proteolysis
Neurovascular-derived microparticles: potential biomarkers and fibrinolytic messenger in stroke
Tissue-type plasminogen activation, the blood brain barrier and traumatic brain injury
Quantitation of net tissue-type plasminogen activator activity following CNS stimulation and injury using a rapid and reliable amidolytic assay
Brain plasminogen system
Combination of intra-arterial thrombolysis and mechanical treatment for acute ischemic stroke
Improving stroke thrombolysis (tPA) safety through the use of plasma biomarkers
Thromboprophylaxis by cell-bound thrombolytics
Epithelial development and homeostasis require complex interactions between matriptase and the Kunitz-type transmembrane serine protease inhibitors, HAI-1 and HAI-2
Protease signaling contributes to neural tube closure
Proteolysis of human Factor IX and FIXa: gla-dependant conformational specificity in its inactivation by plasmin
Thresholding behaviour in prothrombin activation by prothrombinase
Reduced thromboxane production in morbidly obese subjects: another facet of the ‘obesity paradox’
Succesful treatment of massive hemorrhage with FFP, tranexamic acid and fibrinogen concentrate
Increased clot sensitivity to lysis following hemorrhage/trauma does not correlate with increased base deficit
Is hyperfibrinolysis a marker of poor survival in trauma patients?
Effect of warfarin at different intensities on fibrinolysis and coagulation
The thrombin generation test as a tool to compare effects of anticoagulants on clot stability
Clot resistance against tPA-induced fibrinolysis in ROTEM test: an additional tool to evaluate hemostasis and bleeding tendency
Adipose-derived stem cells combined with fibrin matrix of low component concentration for in vivo soft tissue constructs
In vitro effects of detergent sclerosants on clot formation and lysis
The impact of coagulation Factor XII on clot structure and resistance to lysis
Apolipoprotein(a) reduces fibrin clot permeability
Molecular weight fibrinogen variants alter endothelial cell characteristics
The association of thrombin generation with deep venous thrombosis is age-dependent
High-density lipoprotein accelerates degradation of a blood clot as measured by thromboelastography
Tissue-type plasminogen activator in human bile results in accelerated lysis of plasma clots or fibrin sealants
The association between alcohol consumption, PAI-1 and fibrinogen in black South Africans
Different factors contribute to hypofibrinolysis in obese children
Vitronectin levels predict metabolic syndrome and diabetes mellitus risks through a PAI-1 dependent mechanism: the D.E.S.I.R. prospective cohort
The elevated levels of soluble uPAR in diabetes patient associate with renal dysfunction.
Influence of the inhibitors of fibrinolytic system (FS) and renin-angiotensin system (RAS) on inflammatory process
Perioperative levels of alpha-2-antiplasmin and plasminogen in patients undergoing surgery for colon cancer
Thyroid hormones T3 and T4 and their relationship with fibrinolysis variables
Hypofibrinolysis accounts only in part for alteration of clot lysis time in patients with prior pulmonary embolism without pulmonary hypertension
A hypercoagulable and hypofibrinolytic state is detectable by global methods in patients with retinal vein occlusion
The complex of activated protein C and protein C inhibitor (APC-PCI) in diabetics treated with atorvastatin
Allele-specific transcription of the plasminogen activator inhibitor (PAI-1) gene in human astrocytes under in vivo conditions
Stimulation of plasminogen activator activity and apoptosis by lipid peroxidation in n-3-PUFA-enriched rabbit spermatozoa. Protective effect of green tea catechins
Induction of plasminogen activator inhibitor 1 (PAI-1) in murine liver by gadolinium is Kupffer cell independent
Potential role of heparin cofactor II in the regulation of fibrinolysis
PAI-1 and PAI-2 interact with different subunits of proteasome in endothelial cells
Theaflavin digallate inactivates plasminogen activator inhibitor (PAI-1)
Comparative study of commercially available proCPU (TAFI) assays
Shifts of thrombin-activatable fibrinolysis inhibitor in rats after treatment by hormones of hypothalamic-pituitary-thyroid axis
Modulation of TAFI properties by TAFI peptides
Alpha 2-antiplasmin is associated with the progression of fibrosis
Microparticles are increased in thrombectomyaspirated blood of ST-elevation myocardial infarction patients and correlate with fibrinogen and thrombus burden
Diagnostic utility of the fibrinolytic markers in patients with AL amyloidosis
A score for all thrombin generation variables associates with known risk factors in patients with deep venous thrombosis
Fibrinogen elastase degradation products and deep venous thrombosis
APC-PCI complex as new tool for the evaluation of anticoagulant response to endogenous thrombin formation and its sequel in fibrinolysis
The between-laboratory variation for PAI-1, t-PA, plasmin inhibitor and plasminogen. Results of an ECAT survey
Active levels of plasminogen activator inhibitor type 1 (PAI-1) and plasminogen in plasma of patients with acute myocardial infarction (AMI)
Dietary supplementation of vitamins C or E increases tissue plasminogen activator activity in healthy Wistar rat brain
Plasminogen activator activity stimulation by endosulfan-induced lipid peroxidation in Wistar rat brain. Ameliorating effect of vitamin C and E
Effects of the hormones of hypothalamic-pituitarythyroid axis on reptilase time, fibrin degradation products and D-dimer in rats
Modulation of adipose tissue mass by matrix metalloproteinase inhibition
Specificity studies of proteinases from Vipera lebetina snake venom
A pseudozymogen form of matriptase exhibits the optimal activity under conditions of acidic pH and low ionic strength
Effect of natto on tissue plasminogen activator release in perfused rat hindlegs
Zedoary (Curcuma zedoaria Rroscoe) inhibits platelet aggregation and generates t-PA
Nattokinase as thermally stable and broad spectrum enzyme
Plasmin and α2-antiplasmin modulate bone metabolism by regulating the osteoblast and osteoclast function
In vitro effects of detergent sclerosants on fibrinolytic enzymes and inhibitors
Design of sorbtion of thrombin on Procion Blue HB-silicious affinity sorbent for perfection of preparative purifying of blood clotting factors
Dysregulation of urokinase plasminogen activator system during diabetic wound healing
Plasminogen plays essential role in leukocyte accumulation during liver repair
Mechanism of action of aprotinin and ω-amino acids on fibrinolysis induced by staphylokinase (STA)
Two receptors for PEDF, ATGL and RPSA, are expressed in human adult cardiac myocytes
Fibrinolysis and legal mythology: The demographics of tPA-stroke litigation
Reversible thrombin inhibitors show pleiotropic inhibitory effects targeted at the contact activation route of coagulation.
Involvement of cyanidin-3-glucoside chloride in fibrinolytic potency of vascular endothelial cells
Modification of the tumor microenvironment via GPI-anchored TIMP-1 variants