There is a growing body of evidence to show that mindfulness has a number of useful applications in clinical practice, particularly in the area of psychiatry. Introducing mindfulness practice to an established clinical unit presents a number of challenges. This is especially so in addiction medicine, where there is already a diverse range of models and treatments. This article explores these challenges and recommendations for overcoming them. Although mindfulness practice is generally well-received by patients and staff, ongoing training and research is required for its skillful application in clinical settings. The main conclusion reached is that it is more efficacious to start a new unit based on the principles of mindfulness from the outset.