Xerostomia or dry mouth occurs when there is decreased production of saliva. This condition can lead to oral health complications (eg, dental caries, oral lesions), chewing and swallowing problems, and reduced quality of life. Hemodialysis patients are at increased risk of developing xerostomia because of polypharmacy, fluid restriction, salivary gland dysfunction, oral breathing, and systemic diseases. Drug-induced xerostomia increases the risk of oral diseases in these patients. The health care team needs to assess the symptoms of xerostomia in the hemodialysis population and to apply the latest recommendations for its management. This article describes the risks of drug-induced xerostomia in oral health and its management in patients on HD.