Crohn's disease (CD) is complex to manage nutritionally because of the heterogeneity in clinical presentation and medical conditions that ensue. Patients with CD can be difficult to assess because of persistent inflammation, recurrent CD-related flares affecting intestinal absorption, and unclear surgical histories. In addition, patients managed through a remote home parenteral nutrition program highlight other challenges with nutrition assessment and medical management. The remote management of a complex patient on parenteral nutrition requires the oversight of a skilled, advanced practice registered dietitian nutritionist. This case report illustrates the nutritional care of a patient with CD who is dependent on parenteral nutrition in the home with a peripherally inserted central catheter.