A questionable association of stroke volume and arterial pulse pressure under gravitational stress

    loading  Checking for direct PDF access through Ovid



The purpose of this study was to examine individual stroke volume-pulse pressure (PP) relationships in healthy young men and women.


Sixteen healthy men and women were assessed at baseline and during four 12-minute stages of progressive lower body negative pressure (LBNP) at −15, −30, −45, and −60 mm Hg.


Throughout staged LBNP, systolic blood pressure (105 ± 7.8 vs. 103 ± 8.3 mm Hg) and mean arterial pressure were not statistically different (81 ± 5.6 vs. 83 ± 5.9 mm Hg). There was also a significant increase in diastolic blood pressure (69 ± 5.3 vs. 72 ± 5.9 mm Hg) and heart rate (63 ± 8.3 vs. 86 ± 14.2 bpm) as well as a decrease in PP (37 ± 5.7 vs. 31 ± 7.0 mm Hg) and stroke volume (80 ± 17.0 vs. 26.6 ± 10.0 mL). There was a strong positive relationship for LBNP versus stroke volume (r2 = 0.99), PP (r2 = 0.96), and heart rate (r2 = −0.92), as well as for stroke volume versus PP (r2 = 0.98) and stroke volume versus heart rate (r2 = −0.94). Substantial intersubject variability in the stroke volume and PP correlations were presented. Strong, significant correlations were only displayed for 38% of the participants, while heart rate and stroke volume was strongly associated in 63% of these individuals.


This work highlights the limitations of using PP when assessing trauma patients because of large interindividual differences.

Related Topics

    loading  Loading Related Articles