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Hypertension affects as many as 50 million Americans and is a significant risk factor for cerebrovascular disease, cardiovascular disease, renal disease, and mortality. The older population has the highest prevalence of hypertension but responds well to hypertension management, including lifestyle modification and pharmacologic therapy. Pharmacologic management includes the use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-adrenoreceptor blockers, calcium channel blockers, diuretic agents, vasodilator agents, peripheral alpha-blockers, and central alpha-agonists. Special considerations for older adults on antihypertensive medications exist. Rehabilitation professionals ensure safe patient participation in rehabilitation by being cognizant of these considerations.