Beta-defensin genes of the Colubridae snakesPhalotris mertensi,Thamnodynastes hypoconia, andT. strigatus

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Abstract

β-Defensins are cationic antimicrobial peptides showing little sequence similarity but highly conserved tertiary structure stabilized by a six-cysteines-motif. Using a PCR approach, we described β-defensin sequences with two exons in three species of Colubridae snakes with high sequence similarity between them. The deduced amino acid sequence presented the characteristics of β-defensin family. The phylogenetic analysis using β-defensin coding sequences of different snakes grouped them in two main branches: genes organized in three or two exons.

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