Sedaxane–Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors
Arsenic attenuates Heparin-binding EGF-like growth factor/EGFR signalling that promotes matrix-metalloprotease-9-dependent astrocyte damage in the developing rat brain
Organophosphorus compounds at 80 : some old and new issues
Effects of Cyclophosphamide (CYP) and/or Doxorubicin (DOX) in a Murine Model of Post-Chemotherapy Cognitive Impairment
Caspase inhibition reduces hepatic tissue factor-driven coagulation in vitro and in vivo
The Roles of P53 and its Family Proteins, P63 and P73, in the DNA Damage Stress Response in Organogenesis Stage Mouse Embryos
Exposure of mice to 1, 2-dichloropropane induces CYP450-dependent proliferation and apoptosis of cholangiocytes
Identification of a critical window for ganciclovir-induced disruption of testicular development in rats.
Demodifying RNA for Transcriptomic Analyses of Archival Formalin-Fixed Paraffin-Embedded Samples
Screening the Toxcast Phase 1 Chemical Library For Inhibition of Deiodinase Type 1 Activity.
Response to letter from Rainer Otter regarding Albert O. et al. (2017). Identifying Greener and Safer Plasticizers : a Four-Step Approach.
Microcystin-LR induces tau pathology through Bα degradation via PP2A demethylation and associated GSK-3β phosphorylation
Letter to the editor regarding Albert O. et al. (2017). Identifying Greener and Safer Plasticizers : a Four-Step Approach.
Insulin Resistance Disrupts the Interaction Between AKT and the NMDA Receptor and the Inactivation of the CaMKIV/CREB Pathway in Minimal Hepatic Encephalopathy
CircLRP6 Regulation of ZEB1 via miR-455 Is Involved in the Epithelial-Mesenchymal Transition During Arsenite-Induced Malignant Transformation of Human Keratinocytes
High-throughput H295R steroidogenesis assay : utility as an alternative and a statistical approach to characterize effects on steroidogenesis
Dioxin-like PCB 126 increases systemic inflammation and accelerates atherosclerosis in lean LDL receptor deficient mice
Food and Feed Safety of Genetically Engineered Food Crops
Local and systemic inflammation may mediate diesel engine exhaust induced lung function impairment in a Chinese occupational cohort
A 3D human airway model enables prediction of respiratory toxicity of inhaled drugs in vitro
Skeletal muscle interleukin-6 regulates hepatic cytochrome P450 expression; effects of 16 weeks high fat diet and exercise
Toxicokinetics of Deltamethrin : Dosage Dependency, Vehicle Effects, and Low-Dose Age-Equivalent Dosimetry in Rats
Exposure to Concentrated Ambient PM2.5 Compromises Spermatogenesis in a Mouse Model : Role of Suppression of Hypothalamus-Pituitary-Gonads Axis
Microglia Activation and Gene Expression Alteration of Neurotrophins in the Hippocampus Following Early-Life Exposure to E-Cigarette Aerosols in a Murine Model
Generating modelling data from repeat-dose toxicity reports
Uncoupling Effect of F16 Is Responsible for Its Mitochondrial Toxicity and Anticancer Activity
Novel Pathways of Endocrine Disruption Through Pesticides Interference With Human Mineralocorticoid Receptors
Pyrethroid Insecticide Cypermethrin Modulates Gonadotropin Synthesis via Calcium Homeostasis and ERK1/2 Signaling in LβT2 Mouse Pituitary Cells
A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions
Paternal Exposure to Environmental Chemical Stress Affects Male Offspring’s Hepatic Mitochondria
Planarians customize their stem cell responses following genotoxic stress as a function of exposure time and regenerative state
Asking the Right Questions With Animal Models : Methionine- and Choline-Deficient Model in Predicting Adverse Drug Reactions in Human NASH
Variation in Methylmercury Metabolism and Elimination Status in Humans Following Fish Consumption
Quantification of the Effect of Toxicants on the Intracellular Kinetic Energy and Cross-Sectional Area of Mammary Epithelial Organoids by OCT Fluctuation Spectroscopy
Sexually Dimorphic Impact of Chromium Accumulation on Human Placental Oxidative Stress and Apoptosis
Natural Polyphenol Chlorogenic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Activating ERK/Nrf2 Antioxidative Pathway
Ethylene Glycol Teratogenicity : A Role for Embryonic Acidosis?
Effects of Intraperitoneal Injection of SnS2 Flowers on Mouse Testicle
Early Postnatal Exposure to Airborne Fine Particulate Matter Induces Autism-like Phenotypes in Male Rats
Arsenic induces members of the mmu-miR-466-669 cluster which reduces NeuroD1 expression
Effect of Benzo[a]Pyrene on Spindle Misorientation and Fidelity of Chromosome Segregation in Lung Epithelial BEAS-2B Cells
Predicting Drug Safety and Communicating Risk : Benefits of a Bayesian Approach
Multiscale Mathematical Model of Drug-Induced Proximal Tubule Injury : Linking Urinary Biomarkers to Epithelial Cell Injury and Renal Dysfunction
Alteration of Bile Acid and Cholesterol Biosynthesis and Transport by Perfluorononanoic Acid (PFNA) in Mice
Organophosphate Flame-Retardants Alter Adult Mouse Homeostasis and Gene Expression in a Sex-Dependent Manner Potentially Through Interactions With ERα
Scaling-Up Ionic Liquid-Based Technologies : How Much Do We Care About Their Toxicity? Prima Facie Information on 1-Ethyl-3-Methylimidazolium Acetate
Insights Into a Possible Influence on Gut Microbiota and Intestinal Barrier Function During Chronic Exposure of Mice to Imazalil
Effects of Systematic Variation in Size and Surface Coating of Silver Nanoparticles on Their In Vitro Toxicity to Macrophage RAW 264.7 Cells
The Identification of Pivotal Transcriptional Factors Mediating Cell Responses to Drugs With Drug-Induced Liver Injury Liabilities
Developmental Effects of Cannabidiol and Δ9-Tetrahydrocannabinol in Zebrafish
Metabolic Syndrome and Associated Diseases : From the Bench to the Clinic
Nonionic Ethoxylated Surfactants Induce Adipogenesis in 3T3-L1 Cells
Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals
An Impaired Immune Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone and Tolcapone/Entacapone to Cause IDILI
Zebrafish Locomotor Responses Reveal Irritant Effects of Fine Particulate Matter Extracts and a Role for TRPA1
Sustainable Production of Fine Chemicals and Materials Using Nontoxic Renewable Sources
TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation
Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity
Roles of mmu_piR_003399 in Microcystin-Leucine Arginine-Induced Reproductive Toxicity in the Spermatogonial Cells and Testis
A Genome-wide Screening of Target Genes Against Silver Nanoparticles in Fission Yeast
Inhibitors of Nicotinamide Phosphoribosyltransferase Cause Retinal Damage in Larval Zebrafish
Dioxin Exposure Alters Molecular and Morphological Responses to Thyroid Hormone in Xenopus laevis Cultured Cells and Prometamorphic Tadpoles
7,8-Dihydroxyflavone Rescues Lead-Induced Impairment of Vesicular Release : A Novel Therapeutic Approach for Lead Intoxicated Children
Fragrance Allergens Linalool and Limonene Allylic Hydroperoxides in Skin Allergy : Mechanisms of Action Focusing on Transcription Factor Nrf2
Rapid Novel Facile Biosynthesized Silver Nanoparticles From Bacterial Release Induce Biogenicity and Concentration Dependent In Vivo Cytotoxicity With Embryonic Zebrafish—A Mechanistic Insight
miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model
Differential Effects of Exposure to Single Versus a Mixture of Endocrine-Disrupting Chemicals on Steroidogenesis Pathway in Mouse Testes
Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration
Cadmium Exposure Impairs Cognition and Olfactory Memory in Male C57BL/6 Mice
lncRNAL20992 Regulates Apoptotic Proteins to Promote Lead-Induced Neuronal Apoptosis
The Need for, and the Role of the Toxicological Chemist in the Design of Safer Chemicals
Fenretinide, Troglitazone, and Elmiron Add to Weight of Evidence Support for Hemangiosarcoma Mode-of-Action From Studies in Mice
The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives
A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells
The Molecular Design Research Network
From Classical Toxicology to Tox21 : Some Critical Conceptual and Technological Advances in the Molecular Understanding of the Toxic Response Beginning From the Last Quarter of the 20th Century
Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice
Identifying Greener and Safer Plasticizers : A 4-Step Approach
The Altered DNA Methylome of Chronic Doxorubicin Exposure in Sprague Dawley Rats
Pulmonary Vascular Thrombosis in Rats Exposed to Inhaled Sulfur Mustard
Metabolism Modulation in Different Organs by Silver Nanoparticles : An NMR Metabolomics Study of a Mouse Model
Hepatic Amiodarone Lipotoxicity Is Ameliorated by Genetic and Pharmacological Inhibition of Endoplasmatic Reticulum Stress
Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons
Cardiac and Metabolic Effects of Dietary Selenomethionine Exposure in Adult Zebrafish
Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model
Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice
Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance
PPARβ/δ and PPARγ Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis
An Animal-Free In Vitro Three-Dimensional Testicular Cell Coculture Model for Evaluating Male Reproductive Toxicants
Alcohol Inhibition of the Enzymatic Activity of Glyceraldehyde 3-Phosphate Dehydrogenase Impairs Cardiac Glucose Utilization, Contributing to Alcoholic Cardiomyopathy
Chronic Low-Dose Cadmium Exposure Impairs Cutaneous Wound Healing With Defective Early Inflammatory Responses After Skin Injury
Permitted Daily Exposure of the Androgen Receptor Antagonist Flutamide
A Mechanistic Model for Predicting Lung Inflammogenicity of Oxide Nanoparticles
Insulin Resistance Disrupts the Interaction Between AKT and the NMDA Receptor and the Inactivation of the CaMKIV/CREB Pathway in Minimal Hepatic Encephalopathy
Fasiglifam (TAK-875) : Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury