Special Issue: The Proceedings of the 10th International Congress of Toxicology, Tampere, Finland, July 11–15, 2004. Living in a safe chemical world
Does mechanistic understanding help in risk assessment—the example of dioxins
Toxicological implications of esterases—From molecular structures to functions
What determines the acceptability of genetically modified food that can improve human nutrition?
From hazard identification to weighing the benefits and drawbacks of prevention
Inter-individual susceptibility to environmental toxicants—A current assessment
Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: The case of the aryl hydrocarbon receptor
The human genome project and novel aspects of cytochrome P 450 research
Novel extrahepatic cytochrome P450s
CYP2S1: A short review
Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1
Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosyltransferases
Single nucleotide polymorphism in transcriptional regulatory regions and expression of environmentally responsive genes
Neuroprotective properties of nitric oxide and S -nitrosoglutathione
Roles of thioredoxin in nitric oxide-dependent preconditioning-induced tolerance against MPTP neurotoxin
Ebselen: A thioredoxin reductase-dependent catalyst for α-tocopherol quinone reduction
Arsenic stimulates release of cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition
Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline
Regulation of death receptors—Relevance in cancer therapies
“Fluorescent Cell Chip” for immunotoxicity testing: Development of the c- fos expression reporter cell lines
In vitro assessment of sensitizing activity of low molecular weight compounds
Assessment of sequence homology and cross-reactivity
Thresholds of allergenic proteins in foods
Recent advances using rodent models for predicting human allergenicity
Assessment of hepatotoxic liabilities by transcript profiling
Drug-induced oxidative stress in rat liver from a toxicogenomics perspective
Toxicogenomics concepts and applications to study hepatic effects of food additives and chemicals
Complementary gene and protein expression studies and integrative approaches in toxicogenomics
Extracting meaning from functional genomics experiments
Design issues in toxicogenomics using DNA microarray experiment
Recent developments in preclinical toxicological pathology
Trouble shooting in toxicopathology
Current and emerging challenges in toxicopathology: Carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens
Positron emission tomography in the quantification of cellular and biochemical responses to intrapulmonary particulates
Hepatocarcinogenesis tumor grading correlated with in vivo image-guided 1H-NMR spectroscopy in a rat model
Interdisciplinary neurotoxicity inhalation studies: Carbon disulfide and carbonyl sulfide research in F344 rats
Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging
P-glycoprotein activity and biological response
Recent outcomes in European multicentre projects on ambient particulate air pollution
Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: Further mechanistic studies
Gene–particulate matter–health interactions
Mercury and autoimmunity: implications for occupational and environmental health
DNA adducts: Mass spectrometry methods and future prospects
DNA repair and cyclin D1 polymorphisms and styrene-induced genotoxicity and immunotoxicity
Microbial cell wall agents as an occupational hazard
Low level exposure to chemicals and immune system
Gene–environment interaction and biological monitoring of occupational exposures
Genetic effects of radiofrequency radiation (RFR)
Animal carcinogenicity studies on radiofrequency fields related to mobile phones and base stations
Biomonitoring in occupational health: Scientific, socio-ethical, and regulatory issues
Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species
Evaluation and interpretation of maternal toxicity in Segment II studies: Issues, some answers, and data needs
Predicting the risk of developmental toxicity from in vitro assays
Role of transporters in placental transfer of drugs
Alternatives to animal experimentation: The regulatory background
Research perspectives for pre-screening alternatives to animal experimentation
In silico prediction of harmful effects triggered by drugs and chemicals
Recent developments in the way forward for alternative methods: Formation of national consensus platforms in Europe
Comprehensive non-clinical respiratory evaluation of promising new drugs
Investigation of toxic metabolites during drug development
Current status and burning issues in immunotoxicity testing of drugs
Biomarkers of drug-induced vascular injury
Use of in vitro methods to predict QT prolongation
Mass spectrometry in identification of ecotoxicants including chemical and biological warfare agents
Detoxification of organophosphate nerve agents by bacterial phosphotriesterase
The Tokyo subway sarin attack—lessons learned
Particulate matter and heart disease: Evidence from epidemiological studies
Role of inflammation in cardiopulmonary health effects of PM
Human placental perfusion method in the assessment of transplacental passage of antiepileptic drugs
New models and molecular markers in evaluation of developmental toxicity
Testicular dysgenesis syndrome and the development and occurrence of male reproductive disorders
Male-mediated developmental toxicity
The stress response in gametes and embryos after paternal chemical exposures
How do male germ cells handle DNA damage?
Environmental toxicants cause sperm DNA fragmentation as detected by the Sperm Chromatin Structure Assay (SCSA®)
Umbilical cord cell banking—implications for the future
Placenta—an alternative source of stem cells
Bystander effects, genomic instability, adaptive response, and cancer risk assessment for radiation and chemical exposures
Arsenic, mode of action at biologically plausible low doses: What are the implications for low dose cancer risk?
Nonlinearity and thresholds in dose–response relationships for carcinogenicity due to sampling variation, logarithmic dose scaling, or small differences in individual susceptibility
Population variability in biological adaptive responses to DNA damage and the shapes of carcinogen dose–response curves
Derivation of a chemical-specific adjustment factor (CSAF) for use in the assessment of risk from chronic exposure to ethylene glycol: Application of international programme for chemical safety guidelines
Structure-based thresholds of toxicological concern—guidance for application to substances present at low levels in the diet
How can toxicogenomics inform risk assessment?
Toxicovigilance: A new approach for the hazard identification and risk assessment of toxicants in human beings
The Toxic Exposure Surveillance System (TESS): Risk assessment and real-time toxicovigilance across United States poison centers
An integrated framework for health and ecological risk assessment
A comparison between integrated risk assessment and classical health/environmental assessment: Emerging beneficial properties
Safety assessment of novel foods and strategies to determine their safety in use
Risk assessment of DNA-reactive carcinogens in food
Use of product databases for risk assessment purposes
Before and beyond the precautionary principle: Epistemology of uncertainty in science and law
Non-precautionary aspects of toxicology
Scientific basis for the Precautionary Principle
The ethical basis of the precautionary principle in health care decision making
Ethical and practical issues regarding research in children: The European perspective
Critical issues with clinical research in children: The example of premature infants
Global gene mining and the pharmaceutical industry
Medically assisted reproduction and ethical challenges
Therapeutic cloning: The ethical limits
Priority setting for risk assessment—The benefit of human experience
Acute pesticide poisoning and pesticide registration in Central America
Possibilities and pitfalls for modern biotechnology in the development of African genetic toxicology
Past challenges faced: An overview of current educational activities of IUTOX
Poison control centers in developing countries and Asia's need for toxicology education
Latin America's present and future challenges in toxicology education
Africa's present and future needs in toxicology education: Southern African perspective
Distance learning and toxicology: New horizons for Paracelsus
Distance learning in toxicology: Australia's RMIT program
Distance learning in toxicology: Resident and remote; Scotland, IPCS, IUPAC, and the world
Lessons learned in building a global information network on chemicals (GINC)