A Sorting Nexin 17-Binding Domain Within the LRP1 Cytoplasmic Tail Mediates Receptor Recycling Through the Basolateral Sorting Endosome

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Abstract

Synopsis

SNX17 is an early endosomal protein that allows efficient recycling of membrane receptors, such as LRP1 and LDLR, containing an NPxY motif in the cytoplasmic domain. When expressed in polarized epithelial cells, both receptors distribute basolaterally and recycle through the basolateral sorting endosome (BSE). This study describes in detail the SNX17-binding domain present in the LRP1's cytoplasmic domain and demonstrates that in polarized epithelial cells the function of SNX17 is restricted to the basolateral cargo recycling through the BSE.

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