CORRELATION OF TISSUE TYPING, MIXED LYMPHOCYTE CULTURE, AND RELATED DONOR RENAL ALLOGRAFT SURVIVAL

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Abstract

Results of mixed lymphocyte culture reactions and tissue typing were correlated with the clinical courses of recipients of living related donor renal allografts. Forty-nine patients tested by the mixed lymphocyte culture technique were divided into two response groups: stimulation index >5 and stimulation index <5. Seventy patients were tested by standard tissue typing methods and were categorized by the number of mismatched antigens. Allograft survival correlated better with low stimulation in mixed lymphocyte culture than with mismatched antigens, suggesting that lymphocyte-defined histocompatibility is more important than serologically defined histocompatibility in selecting the best possible allograft donor.

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