A COMPARISON OF TWO METHODS OF ORTHOTOPIC PANCREAS TRANSPLANTATION IN THE PIG

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Abstract

SUMMARY

A comparison is made between the early results of pancreatic and pancreaticoduodenál transplantation in the pig. In all cases pancreatic venous drainage was physiological, i.e., into the portal vein. Endocrine graft function was tested by oral or i.v. glucose tolerance on the 6th and 7th postoperative days. In addition, daily samples were taken for insulin, immunoreactive glucagon (IRG), and amylase estimation and animals were killed on day 14. Glucose tolerance results of animals with transplants were compared with sham-operated, pancreatec-tomised, or duodenectomised pigs.

SUMMARY

Although daily insulin and glucagon values in both groups of animals with transplants were within normal limits for the first postoperative days, blood sugar levels were persistently elevated except for the 2 days when animals were starved prior to glucose tolerance tests. In addition, in both oral and i.v. glucose tolerance, the insulin and glucagon responses were depressed as compared with sham-operated animals. The responses to oral or i.v. glucose in duodenectomised pigs showed no resemblance to those of pigs with pancreatic or pancreaticoduodenal transplants, suggesting that any peculiarities of response in the pigs with transplants were not the effect of the duodenum. Graft rejection occurred but pancreatitis or evidence of duodenal leakage was not seen at autopsy. These studies suggest that in the pig, transplantation of either the pancreas alone or the pancreas with the duodenum has similar early results and that there might be a place for a clinical trial of transplantation of the pancreas alone.

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