EFFECT OF LIPOPOLYSACCHARIDE ON THE DEVELOPMENT OF CELL-MEDIATED IMMUNITY TO TRANSPLANTATION ANTIGENS

    loading  Checking for direct PDF access through Ovid

Abstract

SUMMARY

Lipopolysaccharide (LPS) from Escherichia coli administered to allografted mice in a single dose of 20 μug influenced the development of cell-mediated immunity to skin donor antigens.

SUMMARY

As an indicator of cell-mediated immunity, donor antigeninduced inhibition of cell migration from spleen explants of allografted animals was used. Cultures of spleen explants were established 16 days after grafting. The antigen-specific inhibition of migration was abolished when LPS was injected either 4 or 2 days before grafting and intensified when LPS was administered on the 2nd day after grafting.

Related Topics

    loading  Loading Related Articles