RECIPIENT BODY SURFACE AREA AS A PREDICTOR OF POSTTRANSPLANT RENAL ALLOGRAFT EVOLUTION1

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Abstract

Background.

The aim of the present study was to analyze whether minor differences in recipient body surface area have any predictive value on renal allograft evolution.

Methods.

For this study, we considered 236 pairs of recipients who received a kidney from the same donor at our center between March 1985 and December 1995. Pairs in whom at least one patient presented any of the following events were excluded: graft loss during the first year of follow-up, diabetes mellitus, noncompliance with treatment, chronic pyelonephritis, and recurrent or de novo glomerulonephritis. Recipients of each pair were classified as large or small according to their body surface area (BSA). The percentage difference of BSA in each pair was calculated, and two cohorts of pairs were defined: BSA difference ≤10% (n=76 pairs) and BSA difference >10% (n=70 pairs).

Results.

The large recipients of the cohort with a BSA difference >10% showed a higher incidence of posttransplant delayed graft function (22/70 vs. 12/70, P=0.075), hypertension at 1 year of follow-up(51/70 vs. 35/70, P=0.006), and a higher serum creatinine level at 1-year follow-up (173 vs. 142 μmol/L,P=0.003), whereas in the cohort with a BSA difference≤10%, posttransplant evolution in large and small recipients was not different. Multivariate analysis showed that recipient BSA was an independent predictor of delayed graft function, posttransplant hypertension, and serum creatinine at 1-year follow-up.

Conclusions.

Relatively small differences in recipient BSA influence renal allograft evolution. Consequently, our data support that recipient size should be taken into consideration for renal allograft allocation.

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