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For decades transplantations have been established treatment options. However, a patient’s care before and after the surgery is complex: in particular the long-term management of the increasing number of elderly patients, co-morbidity and the care of patients with re- and/or multiple transplantations have led to an increasing need for further competencies of nursing staff. The Institute for Nursing Science at the University of Basel introduces PhD students to innovative scientific technique based on the example of people who have received transplanted organs.Institutions which offer transplantations need a wide range of qualified nursing staff with practical expertise. Therefore training for qualified nursing staff has been developed at the Kalaidos University of Applied Sciences for Health Care supported by a graduate health care expert holding a PhD. The “CAS in Transplantation Care” with 450 hours of training delivers specific expertise on the topic of transplantation and encourages reflective dealing with subject-specific developments. Topic-specific knowledge on health care including clinical assessment and communication with patients is covered and supplemented with findings from medical science, pharmacology, law and ethics. Additionally, concepts like self-efficacy and confidence are discussed and an interview with a transplant patient is conducted. The students work on the topics at the University as well as through directed self-study at their workplace. They identify specific individual needs, inform and accompany people affected and possible donors as well as their relatives. After six months of training alongside work the graduates are able to systematically and extensively assess the care needs before and after the transplantation surgery, to plan and carry out an evidence-based evaluation of the treatment of transplantation patients, and to communicate within an inter-professional team. The graduates ensure that their problem-solving is based on current specialist literature and that they are able to actively work in an inter-professional team.The evaluation of the first academic performance on the course is positive throughout: The topics and the patient’s interview have practical relevance, and are very comprehensible and intellectually inspiring. The preparation assignments are instructive and useful in practice. The assessment of the individually compiled performance record shows that the students are able to identify a problem relevant for their workplace (e.g. pollakisuria/nocturia, lack of concentration and/or memory, fear, adherence) and to look for solutions backed up by literature, to apply them and to give recommendations for practice.In the network Transplantation Care Switzerland, experienced health care experts meet up to develop their subject area further. The evaluation of the training, which was formed by a cooperation of the network and the interdisciplinary experts in nursing, medical science, ethics, pedagogy, pharmacology, law shows: The envisaged objectives have been achieved. The nursing staff are sensitized to recognize individual patients’ problem faster and to offer profound solutions.