Left Atrial Longitudinal Strain at the Conduit Phase: A New Additional Parameter in Predicting Elevated Capillary Wedge Pressure in Patients Candidate for Heart Transplant

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Abstract

Background

Estimating elevated capillary wedge pressure (PCWP) in patients with advanced heart failure candidate for heart transplant is challenging. Our aim was to test accuracy of left atrial strain in predicting elevated PCWP in addition to guideline recommended measurements.

Methods

76 heart failure patients underwent right heart catheterization as well as standard and strain echocardiography. Simple logistic regression was used to assess accuracy in predicting PCWP ≥ 18 mmHg.

Results

Several parameters were more powerful in identifying elevated PCWP than the recommended mesurements. At multivable analysis the combination of peak tricuspid regurgitation flow velocity and Left atrial (LA) strain at the conduit phase reached an AUC=0.947 in identifying patients with elevated PCWP, showing significantly higher discriminant power as compared to guideline recommended measurement of diastolic function.

Conclusion

LA strain at the conduit phase coupled with peak tricuspid regurgitation flow velocity has high accuracy in predicting elevated PCWP, outperforming guidelines supported measurements.

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